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Bacitracin information from DrugsUpdate  

See Available Brands of Bacitracin in India

P - Caution when used during pregnancy
L - Caution when used during Lactation

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis.

Pharmacodynamics

Bacitracin prevents transfer of mucopeptides into the growing cell wall thus inhibiting bacterial cell wall synthesis.

Pharmacokinetics

 


Duration: 6-8 hr.


Absorption: Not well absorbed from the GI tract.


Excretion: About 10-40% of a single injected dose is excreted in the urine within 24 hr.


 

Bacitracin Indications / Bacitracin Uses

In Vancomycin-resistant enterococci infections (orally), in Clostridium difficile-associated diarrhoea and colitis (orally), in Staphylococcal infections (i.m) and in Local infections (topical/cutaneous). 

Bacitracin Adverse Reactions / Bacitracin Side Effects

Systemic admin: Nausea, vomiting, hypersensitivity reactions, severe nephrotoxicity, inj site pain.

Precautions

Information Not Available

Special Precautions

Pregnancy, lactation, Avoid prolonged use. IM use may cause renal failure. Do not admin IV (severe thrombophloebitis)

Other Drug Interactions

Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents.

Other Interactions

Information Not Available

Dosage

 


Oral


Vancomycin-resistant enterococci infections


Adult: 20,000-25,000 u every 6 hr for 7-10 days.


Oral


Clostridium difficile-associated diarrhoea and colitis


Adult: 20,000-25,000 u every 6 hr for 7-10 days.


Intramuscular


Staphylococcal infections


Adult: 10,000-25,000 u every 6 hr. Max: 100,000 u/day and 25,000 u/dose. 


Child: Infant >2.5 kg: 1000 u/kg daily in 2-3 div doses; <2.5 kg: 900 u/kg daily in 2 or 3 div doses. Do not admin for >12 days.


Topical/Cutaneous


Local infections


Adult: In combination with neomycin: Apply once or thrice daily, as directed.


Incompatibility: Incompatible in bases containing stearyl alcohol, cholesterol, polyoxyethylene derivatives and sodium laurilsulfate. Rapidly inactivated in bases containing water, macrogols, propylene glycol, glycerol, cetylpyridinium chloride, benzalkonium chloride, ichthammol, phenol and tannic acid.


 

Food(before/after)

Information Not Available

List of Contraindications

Bacitracin and Pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Bacitracin and Lactation

Caution when used during Lactation

Bacitracin and Children

Information Not Available

Bacitracin and Geriatic

Information Not Available

Bacitracin and Other Contraindications

Hypersensitivity; renal impairment

Storage

Information Not Available

Lab interference

Information Not Available

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