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P - Caution when used during pregnancy
L - Caution when used during lactation
Apomorphine is a non-selective dopamine agonist which activates both D1-like and D2-like receptors, with some preference for the latter subtypes.
Apomorphine is a morphine derivative with structural similarities to dopamine. It is a dopamine D1- and D2-receptor agonist.
In Erectile dysfunction and in Refractory motor fluctuations in Parkinson's disease.
Nausea and vomiting; dyskinesia; dizziness; yawning; drowsiness; transient sedation; postural hypotension; neuropsychiatric disturbances; CNS stimulation; increased salivation and perspiration; eosinophilia; rhinitis; pharyngitis; cough; flushing; taste disturbance; vasovagal syndrome. Less frequently syncope, stomatitis and mouth ulcers.
Debilitated or elderly patients; those with history of postural hypotension; pulmonary, CV or endocrine disease; renal or hepatic impairment, uncontrolled hypertension; patients with anatomical penile deformity. Patients receiving apomorphine and levodopa should be screened for haemolytic anaemia. Domperidone should be given for at least 2 days before starting treatment of parkinsonism with apomorphine.
Antipsychotics, CNS dopamine inhibitors, antihypertensives, organic nitrates, entacapone and memantine.
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Caution when used during Lactation.
Respiratory or CNS depression, neuropsychiatric problems, dementia, recent MI, severe unstable angina, severe heart failure, hypotension, pregnancy, breast-feeding. Hypersensitivity to opioids; patients who have an 'on' response to levodopa marked by severe dyskinesia; hypotonia; or psychiatric effects. Combination treatment with other drugs for erectile dysfunction.
Subcutaneous: Store at 25°C. Sublingual: Store at 25°C