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Etodolac information from DrugsUpdate  

See Available Brands of Etodolac in India

P - Contraindicated in preganancy
L - Contraindicated in lactation
FI - Food interaction
LI - Lab interference

Etodolac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins  (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.

Pharmacodynamics

Etodolac is an NSAID derived from pyrano-indoleacetic acid, inhibits cyclooxygenase 2 (COX-2) resulting in decreased prostaglandin precursor formation.

Pharmacokinetics

Onset: Analgesic: 2-4 hrs

Etodolac Indications / Etodolac Uses

Used for osteoarthritis, rheumatoid arthritis and in acute pain

Etodolac Adverse Reactions / Etodolac Side Effects

GI disturbances; CNS effects; hypersensitivity reactions. Rash, pruritus; neuromuscular and skeletal weaknesses; blurred vision.
Potentially Fatal: Acute renal failure; blood disorder; nephrotoxicity; angioedema, arrhythmia, bone marrow suppression, CHF, dyspnoea, erythema multiforme, exfoliative dermatitis, hepatitis, hypertension, peripheral neuropathy, Stevens-Johnson syndrome, syncope, tachycardia, toxic amblyopia, toxic epidermal necrolysis, urticaria.

Precautions

CHF, dehydration, impaired renal, hepatic function, history of GI disease. Elderly, patients receiving anticoagulant.

Special Precautions

Information Not Available

Other Drug Interactions

Increased effect of warfarin, lithium, methotrexate, digoxin, cyclosporin, aspirin. Effect may be reduced with aspirin. Reduced effect of some diuretics and β-blockers. Alcohol  enhances gastric mucosal irritation.

Other Interactions

Peak serum levels and GI distress decreased when taken with food. Cat's claw, dong quai, evening primrose, feverfew, ginkgo, red clover, horse chestnut, green tea and ginseng enhance the antiplatelet effect.

Dosage

Oral
Osteoarthritis
Adult: 600-1000 mg/day in divided doses adjusted according to response.
Max Dosage: 1200 mg daily.
Oral
Rheumatoid arthritis
Adult: 600-1000 mg/day in divided doses adjusted according to response.
Max Dosage: 1200 mg daily.
Oral
Acute pain
Adult: 200-400 mg every 6-8 hr. Max: 1 g/day.

Food(before/after)

Should be taken with food. (Take w/ or immediately after meals.)

List of Contraindications

Etodolac and Pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Etodolac and Lactation

Information Not Available

Etodolac and Geriatic

Information Not Available

Etodolac and Other Contraindications

Peptic ulcer, hypersensitivity to etodolac/NSAIDs. Childn; pregnancy (3rd trimester) and lactation.

Storage

Information Not Available

Lab interference

Information Not Available

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