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Chymotrypsin information from DrugsUpdate  

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Chymotrypsin is a digestive enzyme that can perform proteolysis.Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a tyrosine, tryptophan, or phenylalanine. These amino acids contain an aromatic ring in their sidechain  that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. The hydrophobic and shape complementarity between the peptide substrate P1  sidechain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine at the P1 position.

Pharmacodynamics

Chymotrypsin is a proteolytic enzyme obtained by the activation of chymotrypsinogen extracted from the pancreas of beef that has been used in ophthalmology for the dissection of the zonule of the lens, thus facilitating intracapsular cataract extraction & reducing trauma to the eye. It has also been given for its anti-inflammatory actions eg, in soft-tissue inflammation & oedema.

Pharmacokinetics

Information Not Availbale

Chymotrypsin Indications / Chymotrypsin Uses

Intraocular
Enzymatic zonulysis for intracapsular lens extraction

Chymotrypsin Adverse Reactions / Chymotrypsin Side Effects

IM: Occasionally, severe allergic reactions. Ophthalmological: Increased intraocular pressure, corneal oedema, striation & moderate uveitis

Precautions

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Special Precautions

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Other Drug Interactions

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Other Interactions

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Dosage

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Food(before/after)

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List of Contraindications

Chymotrypsin and Pregnancy

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Chymotrypsin and Lactation

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Chymotrypsin and Children

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Chymotrypsin and Geriatic

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Chymotrypsin and Other Contraindications

Hypersensitivity. High vitreous pressure & a gaping incisional wound, congenital cataracts, patients < 20 yr due to probable lens-vitreous adhesion not responsive to α-chymotrypsin lysis.

Storage

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Lab interference

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