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Cholecalciferol information from DrugsUpdate  

See Available Brands of Cholecalciferol in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food interaction
LI - Lab interference

Cholecalciferol is a form of vitamin D, also called vitamin D3 or calciol.
It is structurally similar to steroids such as testosterone, cholesterol, and cortisol (though vitamin D3 itself is a secosteroid).

Pharmacodynamics

Vit D may have anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant & mood-modulatory activities. Along with parathyroid hormone & calcitonin, regulate serum calcium conc.
Onset: Slow.
Duration: Relatively prolonged duration of action.

Pharmacokinetics

Absorption: Well absorbed from the GI tract. Presence of bile is essential for adequate intestinal absorption. Hence absorption may be decreased in patients with decreased fat absorption.
Distribution: Bound to a specific α-globulin. Can be stored in adipose & muscle tissue for long periods of time. Slowly released from storage sites & skin where it is formed in the presence of sunlight or uv light. May distribute into breast milk.
Metabolism: Hydroxylated in the liver by the enzyme vitamin D 25-hydroxylase to form 25-hydroxycholecalciferol (calcifediol). Further hydroxylated in the kidneys by the enzyme vitamin D1-hydroxylase to form the active metabolites 1,25-dihydroxycholecalciferol (calcitriol). Further metabolism also occurs in the kidneys, including the formation of the 1,24,25-trihydroxy derivatives.
Excretion: Mainly in the bile & faeces with only small amounts appearing in urine.

Cholecalciferol Indications / Cholecalciferol Uses

Oral
Nutritional deficiency

Cholecalciferol Adverse Reactions / Cholecalciferol Side Effects

Hyperphosphataemia or hypercalcaemia (in excessive intake). Associated effects of hypercalcaemia include hypercalciuria, ectopic calcification, & renal & CV damage.

Precautions

Excessive intake may lead to development of hyperphosphataemia or hypercalcaemia. Infants, renal impairment or calculi, heart disease. Monitor plasma phosphate & calcium level. Pregnancy, lactation.

Special Precautions

Information Not Available

Other Drug Interactions

Increased risk of hypercalcaemia if given with thiazide diuretics, calcium or phosphate. Antiepileptics (e.g. carbamazepine, phenobarbitone, phenytoin  & primidone) may increase vitamin D requirements. Rifampicin & isoniazid may reduce efficacy of vitamin D. Corticosteroids may counteract the effect of vitamin D. Digoxin  or any cardiac glycoside. Reduced absorption when taken with cholestyramine, colestipol, mineral oil, orlistat. Ketoconazole.

Dosage

Adult: 10 mcg (400 units) daily. May also be given via IM inj.
Oral
Deficiency due to malabsorption states or liver diseases
Adult: Up to 1 mg (40 000 units) daily. May also be given via IM inj.
Oral
Hypocalcaemia caused by hypoparathyroidism
Adult: Up to 5 mg (200 000 units) daily. May also be given via IM inj.

Food(before/after)

May be taken with or without food

List of Contraindications

Cholecalciferol and Pregnancy

Category A: Controlled studies in women fail to demonstrate a risk to the foetus in the 1st trimester (and there is no evidence of a risk in later trimesters), and the possibility of foetal harm remains remote.                           
if dose > US RDA.
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Cholecalciferol and Lactation

Information Not Available

Cholecalciferol and Children

Information Not Available

Cholecalciferol and Geriatic

Information Not Available

Cholecalciferol and Other Contraindications

Hypercalcaemia. Evidence of vitamin D toxicity

Storage

Information Not Available

Lab interference

Information Not Available

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