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Cefoperazone information from DrugsUpdate  

See Available Brands of Cefoperazone in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Cefoperazone is a third generation cephalosporin  antibiotic. It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics.

Pharmacodynamics

Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Pharmacokinetics

Distribution: Widely distributed into body tissues and fluids; poor CSF penetration. Crosses the placenta and enters breast milk (low concentrations); bile (high concentrations). Protein-binding: 82-93%
Excretion: Mainly via the bile. Via the urine within 12-24 hrs by glomerular filtration (30% as unchanged); proportion may be increased in hepatic or biliary disease.

Cefoperazone Indications / Cefoperazone Uses

Parenteral
Susceptible infections

Cefoperazone Adverse Reactions / Cefoperazone Side Effects

Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection.
Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity.

Precautions

History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis.

Special Precautions

Max dose for liver impairment or biliary obstruction: 4 g daily; liver and kidney impairment: 1-2 g daily.

Other Drug Interactions

Disulfiram-like reaction with alcohol. Potentiates anticoagulants.
Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide.

Other Interactions

Information Not Available

Dosage

Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion.
Renal impairment: With liver impairment: 1-2 g daily.
Hepatic impairment: Max dose for liver impairment or biliary obstruction: 4 g daily.

Food(before/after)

Information Not Available

List of Contraindications

Cefoperazone and Pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Cefoperazone and Lactation

Information Not Available

Cefoperazone and Children

Information Not Available

Cefoperazone and Geriatic

Information Not Available

Cefoperazone and Other Contraindications

Hypersensitivity to cephalosporin

Storage

Parenteral: Store below 25°C

Lab interference

Parenteral: Store below 25°C

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