Drugsupdate.com is up for sale. To own one of the most recognized online brands by doctors in India with millions of visitors - click here.

logo image

Carbimazole information from DrugsUpdate  

See Available Brands of Carbimazole in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Carbimazole is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

Pharmacodynamics

Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase.

Pharmacokinetics

Absorption: Rapid from the GIT (oral); peak plasma concentrations after 1-2 hrs.
Distribution: High concentrations in the thyroid gland; crosses the placenta; enters breast milk.
Metabolism: Hepatic; converted to methimazole.
Excretion: Urine (<12% unchanged drug); 3-6 hrs (elimination half-life).

Carbimazole Indications / Carbimazole Uses

Oral
Hyperthyroidism, Adjunct to radio-iodine therapy, Grave's disease, Preparation for thyroidectomy

Carbimazole Adverse Reactions / Carbimazole Side Effects

Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia.
Potentially Fatal: Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre.

Precautions

Information Not Available

Special Precautions

Liver diseases, pregnancy, lactation

Other Drug Interactions

Potentially Fatal: Increased sensitivity to warfarin  in hyperthyroidism and careful control required as patient is rendered euthyroid.

Other Interactions

Information Not Available

Dosage

Adult: Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth.
Child: 4-12 yr: Initially, 15 mg daily.

Food(before/after)

Information Not Available

List of Contraindications

Carbimazole and Pregnancy

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Carbimazole and Lactation

Information Not Available

Carbimazole and Children

Information Not Available

Carbimazole and Geriatic

Information Not Available

Carbimazole and Other Contraindications

Hyperthyroidism due to nodular goitre

Storage

Oral: Store below 25°C

Lab interference

Oral: Store below 25°C

Carbimazole brands in India:

Anti-Thyrox Neo-Mercazole Thyrocab Thyrozole

© 2011-2020 DrugsUpdate.com. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.