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Alprostadil information from DrugsUpdate  

See Available Brands of Alprostadil in India

P - Contraindicated in Pregnancy

Prostaglandin E1 (PGE1), known pharmaceutically as alprostadil,[1] is a prostaglandin. It is a drug used in the treatment of erectile dysfunction[2] and has vasodilatory properties.

Pharmacodynamics

 


Alprostadil causes vasodilation and prevents platelet aggregation. It has direct effect on the vascular and ductus arteriosus smooth muscle. When injected along the penile shaft, alprostadil relaxes the trabecular smooth muscle by dilation of the cavernosal arteries. This allows blood flow to the lacunar spaces of the penis.


Metabolism: Rapidly metabolised by oxidation during passage through the pulmonary circulation.


Excretion: Excreted in urine as metabolites within 24 hr.


 

Pharmacokinetics

Information Not Available

Alprostadil Indications / Alprostadil Uses

Information Not Available

Alprostadil Adverse Reactions / Alprostadil Side Effects

 


Flushing, bradycardia, hypotension, tachycardia, oedema, diarrhoea, fever, convulsions, DIC, cortical proliferation of long bones, hypokalaemia, weakening of the wall of ductus arteriosus and pulmonary artery may follow prolonged use; gastric outlet obstruction reported.


Potentially Fatal: Cardiac arrest, apnoea (in infants <2 kg).


 

Precautions

Information Not Available

Special Precautions

Neonates receiving PGE1 for more than 120 hr should be closely monitored for antral hyperplasia and gastric outlet obstruction; history of haemorrhage; monitor BP, blood oxygenation and blood pH continually. Caution in COPD.

Other Drug Interactions

Information Not Available

Other Interactions

Avoid ethanol

Dosage

 


Intravenous


Maintenance of patency of ductus arteriosus in neonates with congenital heart disease


Child: 0.05-0.1 mcg/kg/minute by continuous IV infusion, may increase to 0.4 mg/kg/minute. To be injected into a large vein, or alternatively through an umbilical artery catheter placed at the ductal opening. Reduce to the lowest dose necessary to maintain response as soon as possible. 


Intracavernosal


Erectile dysfunction


Adult: Initially, 2.5 mcg, then 5 mcg, further increments may be made in steps of 5-10 mcg depending on erectile response. Once the optimal dose is determined, it should not be given >1 time/day or 3 times/wk. Usual maintenance: 5-20 mcg/day. Max: 60 mcg/day. For neurogenic origin (e.g. spinal cord injury): Initially, 1.25 mcg, may increase to 2.5 mcg, then 5 mcg (if needed).


Intracavernosal


Diagnosis of erectile dysfunction


Adult: 5-20 mcg. A dose of 500 mcg may also be administered trans-urethrally. 


Urethral


Erectile dysfunction


Adult: Initially 250 mcg, may increase to 500 or 1000 mcg or reduce to 125 mcg depending on erectile response. The optimal dose should not be given >2 times/day or 7 times/wk.


 

Food(before/after)

Information Not Available

List of Contraindications

Alprostadil and Pregnancy

 


Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.


Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.


 

Alprostadil and Lactation

Information Not Available

Alprostadil and Children

Information Not Available

Alprostadil and Geriatic

Information Not Available

Alprostadil and Other Contraindications

Hypersensitivity, hyaline membrane disease. Pregnancy

Storage

Information Not Available

Lab interference

Information Not Available

Alprostadil brands in India:

Alpostin Bioglandin Prostin VR

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