Doxofylline is a theophylline derivative. Similarly, its mechanism of action is related to the inhibition of phosphodiesterase activities, resulting in bronchodilating effects.

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Doxofylline has a prolonged bronchodilator effects and unlike theophylline it has least adenosine interactions i.e., no CNS and CVS side effects. There is no sleep disturbances and no effects on gastric secretions with doxofylline. It is highly safe in smokers.

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Adult: 400mg once a day. Single dose administration in the evening reduces nocturnal symptoms and helps to keep the patients complaint free during the day. However, in certain cases 400mg twice daily is recommended on the basis of the clinical response.

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Hypersensitivity to doxofulline and other methyxanthine derivatives. Methyxanthines are not recommended for therapy of asthma exacerbations.

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