Levosulpiride information from DrugsUpdate
L - Caution when used during lactation
A substituted benzamide anti-psychotic, reported to be a selective antagonist of central dopamine (D-2, D-3 and D-4) receptors, Levosulpiride is also calimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses, particularly negative symptoms of schizophrenia, anxiety disorders, dysthymia, vertigo, dyspepsia, irritable bowel syndrome and premature ejaculation.
Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent.
Absorption: Oral bioavailability is about 30%; peak plasma concentrations after about 3 hr.
Excretion: Mainly via urine. Plasma half-life: 9.7 hr (oral); 4.3 hr (IV).
Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido.
Potentially Fatal: Neuroleptic malignant syndrome.
May impair ability to drive or operate machinery. Pregnancy and lactation
Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.
Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia
Adult: 25 mg tid.
Elderly: Dose reductions may be necessary.
List of Contraindications
Caution when used during pregnancy
Caution when used during lactation
Phaeochromocytoma, epilepsy, manic states, hyperprolactinaemia, mammary dysplasia, malignant mastopathies, cardiac impairment. GI bleeding, mechanical obstruction or perforation.
Oral: Store at 15-30°C (59-86°F)