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Levosulpiride information from DrugsUpdate  

See Available Brands of Levosulpiride in India

P - Caution when used during pregnancy
L - Caution when used during lactation

A substituted benzamide anti-psychotic, reported to be a selective antagonist of central dopamine (D-2, D-3 and D-4) receptors, Levosulpiride is also calimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses, particularly negative symptoms of schizophrenia, anxiety disorders, dysthymia, vertigo, dyspepsia, irritable bowel syndrome and premature ejaculation.

Pharmacodynamics

Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent.

Pharmacokinetics

Absorption: Oral bioavailability is about 30%; peak plasma concentrations after about 3 hr.
Excretion: Mainly via urine. Plasma half-life: 9.7 hr (oral); 4.3 hr (IV).

Levosulpiride Indications / Levosulpiride Uses

Information Not Available

Levosulpiride Adverse Reactions / Levosulpiride Side Effects

Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido.
Potentially Fatal: Neuroleptic malignant syndrome.

Precautions

Information Not Available

Special Precautions

May impair ability to drive or operate machinery. Pregnancy and lactation

Other Drug Interactions

Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.

Other Interactions

Information Not Available

Dosage

Oral
Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia
Adult: 25 mg tid.
Elderly: Dose reductions may be necessary.

Food(before/after)

Information Not Available

List of Contraindications

Levosulpiride and Pregnancy

Caution when used during pregnancy

Levosulpiride and Lactation

Caution when used during lactation

Levosulpiride and Children

Information Not Available

Levosulpiride and Geriatic

Information Not Available

Levosulpiride and Other Contraindications

Phaeochromocytoma, epilepsy, manic states, hyperprolactinaemia, mammary dysplasia, malignant mastopathies, cardiac impairment. GI bleeding, mechanical obstruction or perforation.

Storage

Oral: Store at 15-30°C (59-86°F)

Lab interference

Oral: Store at 15-30°C (59-86°F)

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