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Cetirizine + Pseudoephedrine information from DrugsUpdate  

See Available Brands of Cetirizine + Pseudoephedrine in India

P - Caution when used during pregnancy

Cetirizine and pseudoephedrine is a combination of an antihistamine and a decongestant used to treat the symptoms of seasonal or yearly allergies. Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Decongestants produce a narrowing of blood vessels. This leads to clearing of nasal congestion, but it may also cause an increase in blood pressure in patients who have high blood pressure. Pseudoephedrine; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants. Cetirizine; Belongs to the class of piperazine derivatives used as systemic antihistamines.

Pharmacodynamics

Cetirizine is an antihistamine that works mainly via selective inhibition of H1 receptors. Pseudoephedrine hydrochloride is an orally active sympathomimetic amine that exerts a decongestant action on the nasal mucosa. It is used for the relief of nasal congestion due to allergic rhinitis.

Pharmacokinetics

Absorption: Cetirizine: Rapidly absorbed from the GI tract after oral admin. Pseudoephedrine: Readily absorbed after oral admin.
Distribution: Cetirizine: About 93% bound to plasma proteins.
Metabolism: Cetirizine: Limited metabolism by oxidative O-dealkylation to a metabolite with little or no antihistaminic activity. Pseudoephedrine: About 1-7% of a dose is metabolised to nor-pseudoephedrine by N-demethylation.
Excretion: Mean elimination half-life: 7.9 hr (cetirizine) and 6 hr (pseudoephedrine).

Cetirizine + Pseudoephedrine Indications / Cetirizine + Pseudoephedrine Uses

Information Not Available

Cetirizine + Pseudoephedrine Adverse Reactions / Cetirizine + Pseudoephedrine Side Effects

Insomnia, dry mouth, somnolence, fatigue

Precautions

Information Not Available

Special Precautions

Caution when used in patients with hypertension, DM, ischaemic heart disease, increased intraocular pressure, hyperthyroidism, renal impairment or prostatic hypertrophy. May cause CNS stimulation with convulsions or CV collapse with accompanying hypotension. Elderly are more prone to developing the adverse reactions. Pregnancy.

Other Drug Interactions

Concurrent use with digitalis may increase ectopic pacemaker activity. Additive effects on the CV system may occur when used with sympathomimetic amines.
Potentially Fatal: Not to be used concurrently with MAOIs or within 14 days of stopping MAOI treatment.

Other Interactions

Information Not Available

Dosage

Oral
Allergic rhinitis
Adult: Each extended release tablet containing cetirizine 5 mg and pseudoephedrine 120 mg: 1 tablet bid.
Child: ≥12 yr: As extended release tablet each containing cetirizine 5 mg and pseudoephedrine 120 mg: 1 tablet twice daily.
Renal impairment: CrCl: 11–31 ml/min or patients on haemodialysis with CrCl <7 ml/min: 1 tablet once daily is recommended
Hepatic impairment: 1 tablet once daily is recommended.

Food(before/after)

Information Not Available

List of Contraindications

Cetirizine + Pseudoephedrine and Pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Cetirizine + Pseudoephedrine and Lactation

Information Not Available

Cetirizine + Pseudoephedrine and Children

Information Not Available

Cetirizine + Pseudoephedrine and Geriatic

Information Not Available

Cetirizine + Pseudoephedrine and Other Contraindications

Patients with narrow-angle glaucoma or urinary retention. Patients on MAOI treatment or within 14 days of stopping such treatment. Patients with severe hypertension or severe coronary artery disease.

Storage

Oral: Store at 20-25°C

Lab interference

Oral: Store at 20-25°C

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