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Calcium Citrate + Vitamin D3 information from DrugsUpdate  

See Available Brands of Calcium Citrate + Vitamin D3 in India

This combination medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).
Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Having the right amounts of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.

 

Pharmacodynamics

Calcium salt can be used in the prevention and treatment of calcium deficiency states. It is also used as an adjunct in the prevention and treatment of osteoporosis. Vitamin D3 is a fat-soluble sterol. It is necessary for the regulation and regulation of calcium and phosphate homoeostasis and bone mineralisation.

Pharmacokinetics

Absorption: Calcium: Approx 33% of oral calcium absorbed via active transport and passive diffusive in small intestine. Vitamin D3: Well-absorbed from GI tract in the presence of bile.
Distribution: Calcium: Skeletal tissue, breast milk. Crosses placenta. Vitamin D: Vitamin D and metabolites binds to vitamin D -binding protein and are circulated in the blood. May be stored in adipose and muscle tissue for prolonged periods.
Metabolism: Vitamin D3: Hydroxylated in liver to form 25-hydroxycholecalciferol, then hydroxylated in kidney to form active metabolite 1,25-dihydroxycholecalciferol.
Excretion: Calcium salt: Unabsorbed calcium mainly excreted via faeces. Excess absorbed calcium excreted via urine. Vitamin D: Vitamin D and metabolites are mainly excreted in the bile and faeces.

Calcium Citrate + Vitamin D3 Indications / Calcium Citrate + Vitamin D3 Uses

Information Not Available

Calcium Citrate + Vitamin D3 Adverse Reactions / Calcium Citrate + Vitamin D3 Side Effects

Constipation, nausea, abdominal pain, hypercalcaemia, hypercalciuria, headache, muscle weakness.

Precautions

Information Not Available

Special Precautions

Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients on high doses of vitamin D. History of kidney stones. Renal impairment.

Other Drug Interactions

Reduced absorption of tetracyclines, quinolones and oral biphosphates with concurrent calcium use. Calcium absorption may be reduced by corticosteriods. Increased risk of hypercalcemia and metabolic alkalosis with thiazide diuretics. High blood calcium level may increase the effect of caridac glycosides. Reduced erlotinib efficacy with calcium. Increased risk of hypercalaemia with paricalcitol. Enzyme-inducing antiepileptics increases the metabolism of Vit D.
Potentially Fatal: Fatal encephalopathy can occur in patients with renal failure when given calcium citrate and aluminium products concurrently due to marked rise in aluminium levels.

Other Interactions

Food Interactions: Foods that are rich in oxalic acid (e.g. spinach and rhubarb) and phytic acid (e.g. whole cereals) may reduce calcium absorption by formation of insoluble calcium salts.

Dosage

Oral
Supplementation of calcium and vitamin D3
Adult: Calcium (expressed in terms of elemental calcium): 19-50 yr: 1000 mg/day and >50 yr: 1200 mg/day. Vitamin D3: 10 mcg daily. 20 mcg daily for patients with limited sunlight exposure, low vitamin D diet or bedridden elderly patients.
Renal impairment: Use with caution in renal failure. Frequent monitoring of serum calcium and phosphorus needed.

Food(before/after)

Information Not Available

List of Contraindications

Calcium Citrate + Vitamin D3 and Pregnancy

Information Not Available

Calcium Citrate + Vitamin D3 and Lactation

Information Not Available

Calcium Citrate + Vitamin D3 and Children

Information Not Available

Calcium Citrate + Vitamin D3 and Geriatic

Information Not Available

Calcium Citrate + Vitamin D3 and Other Contraindications

Patients with hypercalcaemia, hypercalciuria or hypophosphatemia. Nephrolithiasis, hypervitaminosis D.

Storage

Information Not Available

Lab interference

Information Not Available

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