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Domperidone + Paracetamol information from DrugsUpdate  

See Available Brands of Domperidone + Paracetamol in India

Domperidone; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders. Paracetamol; Belongs to the class of anilide preparations. Used to relieve pain and fever.

Pharmacodynamics

Domperidone is a dopamine antagonist which works to prevent vomiting (symptom of migraine). Domperidone is given with paracetamol, an analgesic, for relief of migraine.

Pharmacokinetics

Information Not Available

Domperidone + Paracetamol Indications / Domperidone + Paracetamol Uses

Information Not Available

Domperidone + Paracetamol Adverse Reactions / Domperidone + Paracetamol Side Effects

Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhoea, lassitude, decreased libido, nausea, allergic reactions, skin rashes, acute renal tubular necrosis.
Potentially Fatal: Domperidone: convulsions, arrhythmias and cardiac arrest, dysrhythmias in patients with CV disease or hypokalaemia, patients on cancer chemotherapy. Seizures, hypertensive crisis in patients with pheochromocytoma are seen.
Paracetamol, very rare, blood dyscrasias (eg, thrombocytopaenia, leucopaenia, neutropaenia, agranulocytosis); liver damage are seen.

Precautions

Information Not Available

Special Precautions

Phaeochromocytoma; children, elderly; renal or hepatic impairment, risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy, lactation and alcohol-dependent patients.

Other Drug Interactions

Domperidone reduces absorption of oral digoxin, increases absorption of aspirin and oral diazepam. Enhances CNS depression by phenothiazines. Antimuscarinic agents and opioids antagonise GI effects of domperidone.
Paracetamol reduced absorption of cholestyramine within 1 hr of admin and accelerates absorption of metoclopramide.
Potentially Fatal: Paracetamol increases the risk of liver damage in chronic alcoholics. Increased risk of toxicity with other hepatotoxic drugs or drugs which induce microsomal enzymes.

Other Interactions

Food interactions: Delayed absorption of domperidone but higher bioavailability due to reduced first-pass metabolism in gut wall. Decreased rate of absorption of paracetamol with food.

Dosage

Oral
Migraine
Adult: 2 tab (20 mg domperidone/1000 mg paracetamol) at onset of migraine attack. Repeat up to every 4 hr if required. Max: 4 g paracatamol/day.
Max Dosage: 8 tab (4 doses) in 24 hr.

Food(before/after)

Information Not Available

List of Contraindications

Domperidone + Paracetamol and Pregnancy

Information Not Available

Domperidone + Paracetamol and Lactation

Information Not Available

Domperidone + Paracetamol and Children

Information Not Available

Domperidone + Paracetamol and Geriatic

Information Not Available

Domperidone + Paracetamol and Other Contraindications

Hypersensitivity. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone or chronic admin or for prophylaxis of postoperative nausea and vomiting.

Storage

Information Not Available

Lab interference

Information Not Available

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