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Pseudoephedrine information from DrugsUpdate  

See Available Brands of Pseudoephedrine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It is used as a nasal/sinus decongestant and stimulant, or as a wakefulness-promoting agent.
The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as a single ingredient or, more commonly, in combination with antihistamines, guaifenesin, dextromethorphan, paracetamol (acetaminophen), and/or NSAIDs (e.g., aspirin, ibuprofen, etc.).

Pharmacodynamics

Causes vasoconstriction and subsequent shrinkage of nasal mucous membranes by alpha-adrenergic stimulation, promoting nasal drainage.

Pharmacokinetics

Distribution
Distributes into breast milk.
Metabolism
Partially metabolized in the liver.
Elimination
Renal (55% to 75% as unchanged); acidic urine accelerates rate of excretion.
Onset
15 to 30 min.
Peak
30 to 60 min.
Duration
3 to 4 h; 8 to 12 h (extended-release).

Pseudoephedrine Adverse Reactions / Pseudoephedrine Side Effects

Cardiovascular
Arrhythmias; CV collapse with hypotension; tachycardia; bradycardia; transient hypertension.
CNS
Nervousness; excitability; dizziness; tremor; insomnia; restlessness; depression.
Dermatologic
Pallor.
GI
Anorexia; nausea; vomiting; dry mouth.
Genitourinary
Difficulty urinating.

Precautions

Information Not Available

Special Precautions

Information Not Available

Other Drug Interactions

Furazolidone, guanethidine, methyldopa
Increased BP.
MAOIs
Severe headache, hypertension and hyperpyrexia; can cause hypertensive crisis.
Urinary acidifiers (eg, ammonium chloride)
Increased elimination of pseudoephedrine.
Urinary alkalinizers (eg, sodium bicarbonate)
Decreased elimination of pseudoephedrine.

Other Interactions

Information Not Available

Dosage

Information Not Available

Food(before/after)

Information Not Available

List of Contraindications

Pseudoephedrine and Pregnancy

Category C

Pseudoephedrine and Lactation

Do not give to breast-feeding mothers

Pseudoephedrine and Children

Use drug only under health care provider's advice in children under 3 months

Pseudoephedrine and Geriatic

Ensure that short-acting product is tolerated before giving sustained-release product.

Pseudoephedrine and Other Contraindications

Hypersensitivity to sympathomimetic amines; severe hypertension; coronary artery disease; MAOIs therapy; breast-feeding mothers.

Storage

Store at room temperature

Lab interference

Store at room temperature

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