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Tryptophan information from DrugsUpdate  

See Available Brands of Tryptophan in India

Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG. Twiptophan can be used as a mnemonic for the single letter code W. Only the L-stereoisomer of tryptophan is used in structural or enzyme proteins, but the D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). The distinguishing structural characteristic of tryptophan is that it contains an indole functional group. It is an essential amino acid as defined by its growth effects on rats.

Pharmacodynamics

Pharmacokinetics

Information Not Available

Tryptophan Indications / Tryptophan Uses

Information Not Available

Tryptophan Adverse Reactions / Tryptophan Side Effects

Nausea (take after food to minimise nausea), headache, lightheadedness, drowsiness, eosinophilia-myalgia syndrome.

Precautions

Information Not Available

Special Precautions

May affect ability to drive or operate machinery. Monitor for suicidal thoughts or clinical worsening of depression during initial treatment period. Renal or hepatic impairment. Elderly.

Other Drug Interactions

Increased risk of serotonin syndrome with SSRI. Possible decrease in levodopa plasma levels with tryptophan. Increased risk of severe behavioural and neurological toxicity with MAOI, start with lower initial dose of tryptophan if needed.

Other Interactions

Information Not Available

Dosage

Adjunct in treatment resistant depression
Adult: As L-tryptophan: 1g tid. Max. 6g daily.
Elderly: Dose reduction may be needed.

Food(before/after)

After food

List of Contraindications

Tryptophan and Pregnancy

Information Not Available

Tryptophan and Lactation

Information Not Available

Tryptophan and Children

Studies on tryptophan have been done only in adult patients, and there is no specific information comparing use of L-tryptophan in children with use in other age groups.

Tryptophan and Geriatic

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of L-tryptophan in the elderly with use in other age groups.

Tryptophan and Other Contraindications

History of eosinophilia-myalgia syndrome associated with tryptophan treatment

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.

Lab interference

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.

Tryptophan brands in India:

5-HTPn Amifull Minotec Tophan

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