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Drotaverine information from DrugsUpdate  

See Available Brands of Drotaverine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Drotaverine is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.
A small 2003 study found drotaverine to be nearly 80% effective in treating renal colic. It has also been used to accelerate labor.

Pharmacodynamics

Pharmacokinetics

Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.

Drotaverine Indications / Drotaverine Uses

Information Not Available

Drotaverine Adverse Reactions / Drotaverine Side Effects

Vertigo, nausea, vomiting, dry mouth

Precautions

Information Not Available

Special Precautions

Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.

Other Drug Interactions

May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.

Other Interactions

Information Not Available

Dosage

Oral
Antispasmodic
Adult: 40-80 mg tid.
Child: 1-6 yr: 20 mg 3-4 times daiily; >6 yr: 40 mg tid.

Food(before/after)

May be taken with or without food

List of Contraindications

Drotaverine and Pregnancy

Caution when used during pregnancy

Drotaverine and Lactation

Caution when used during lactation

Drotaverine and Children

Information Not Available

Drotaverine and Geriatic

Information Not Available

Drotaverine and Other Contraindications

Severe renal/hepatic/cardiac dysfunction. Porphyria.

Storage

Information Not Available

Lab interference

Information Not Available

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