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Dopamine information from DrugsUpdate  

See Available Brands of Dopamine in India

P - Caution when used during pregnancy

Dopamine is a neurotransmitter that occurs in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4, and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area.[1] Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary.
Dopamine can be supplied as a medication that acts on the sympathetic nervous system, producing effects such as increased heart rate and blood pressure. However, because dopamine cannot cross the blood-brain barrier, dopamine given as a drug does not directly affect the central nervous system. To increase the amount of dopamine in the brains of patients with diseases such as Parkinson's disease and dopa-responsive dystonia, L-DOPA, which is the precursor of dopamine, can be given because it can cross the blood-brain barrier.

Pharmacodynamics

Pharmacokinetics

Dopamine stimulates dopaminergic receptors at lower doses producing renal and mesenteric vasodilation while at higher doses stimulate both dopaminergic and β-adrenergic receptors producing cardiac stimulation and renal vasodilation. It increases heart rate and force of contraction. At low infusion rates vasodilatation occurs in the renal, mesenteric, coronary and cerebral beds. At higher rates vasoconstriction in skeletal muscles and a rise in BP.
Absorption: Inactivated in the GI tract and body (oral).
Metabolism: Into dopamine-related products; converted to noradrenaline.
Excretion: Eliminated as metabolic products of noradrenaline; 2 min (elimination half-life).

Dopamine Indications / Dopamine Uses

Information Not Available

Dopamine Adverse Reactions / Dopamine Side Effects

Nausea, vomiting, tachycardia, ectopic beats, palpitation, anginal pain, hypotension, vasoconstriction, bradycardia, hypertension, dyspnoea, headache, widened QRS complexes, azotaemia.

Precautions

Information Not Available

Special Precautions

Shock secondary to MI, history of peripheral vascular disease. Correct hypovolaemia before infusion. History of occlusive vascular disease e.g, atherosclerosis, Raynaud's disease, Buerger's disease, diabetic endarteritis; disproportionate increase in diastolic pressure. Pregnancy.

Other Drug Interactions

Cyclopropane and halogenated hydrocarbon anaesthetics may sensitise myocardium to dopamine and precipitate ventricular arrhythmias. MAO inhibitors prolong and increase dopamine effects. Ergots potentiate vasoconstriction action of dopamine. Alpha-blockers unmask dopamine's beta action.

Other Interactions

Information Not Available

Dosage

Intravenous
Acute heart failure
Adult: As hydrochloride: Initially, 1-5 mcg/kg/min increased gradually by up to 5-10 mcg/kg/min according to the patient's BP, cardiac output and urine output. Up to 20-50 mcg/kg/min may be required in seriously ill patients.

Food(before/after)

Information Not Available

List of Contraindications

Dopamine and Pregnancy

Caution when used during pregnancy.
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Dopamine and Lactation

Information Not Available

Dopamine and Children

Information Not Available

Dopamine and Geriatic

Information Not Available

Dopamine and Other Contraindications

Pheochromocytoma, uncorrected tachyarrhythmias, ventricular fibrillation, Hypersensitivity

Storage

Intravenous: Store below 30°C.

Lab interference

Intravenous: Store below 30°C.

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