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Domperidone information from DrugsUpdate  

See Available Brands of Domperidone in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Domperidone (trade names Motilium, Motillium, Motinorm and Costi) is an antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting. It has also been used to stimulate lactation.



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Domperidone Indications / Domperidone Uses

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Domperidone Adverse Reactions / Domperidone Side Effects

Drowsiness, extrapyramidal reactions, galactorrhoea, gyneacomastia; constipation or diarrhoea, lassitude, decreased libido, skin rash, itch. Convulsions, arrhythmias & cardiac arrest, dysrrhythmia in patinents with CV disease or hypocalcemia, patients on cancer chemotherapy, Seizures; hypertensive crisis in patients with phaeochromocytoma.


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Special Precautions

Phaeochromocytoma; children <2yrs, elderly; renal or hepatic impairment. Risk of cardiac arrhythmias & hypokalemia if administered IV. Pregnancy & Lactation.

Other Drug Interactions

Reduces abosrption of digoxin. Increases abosrption of aspirin, paracetamol & oral diazepam. Enhances CNS depresssion by phenothiazine. Antimuscarinic agents & opioids antagonise GI effects.
May antagonise hypoprolactinaemic effect of drugs such as bromocriptine. Increased effects when used    with CYP3A4 inhibitors such as erthromycin or ritonavir.

Other Interactions

Food Interactions


Acute treatment of nausea & vomiting:
Adult: 10-20mg every 4-8 hrs. Max 80mg/day.
Child: >2 yr & > 35 kg: 10-20 mg 3-4 times daily. Max 80mg daily.
Adult: 20 mg every 4 hours, in combination with paracetamol, as required. Max: 4 doses in 24 hours.
Acute treatment of nausea & vomiting: Adult 60 mg bid.
Child: 60 mg bid.


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List of Contraindications

Domperidone and Pregnancy

Cautioned in pregnancy

Domperidone and Lactation

Cautioned in lactation

Domperidone and Children

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Domperidone and Geriatic

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Domperidone and Other Contraindications

Hypersensitivity. GI haemorrage, obstruction & perforation, patients with prolactin releases pitutary hormone, chronic admin or routine prophylaxis of postoperative nausea & vomiting.


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Lab interference

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