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Mecobalamin information from DrugsUpdate  

See Available Brands of Mecobalamin in India

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Methylcobalamin is a cobalamin (MeB12) used in peripheral neuropathy, diabetic neuropathy etc. It is a form of vitamin B12. This vitamer is one of two active coenzymes used by B-12 dependent enzymes in the body, and is specifically the B-12 form used by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase.

 

Methylcobalamin is notable for being one of the few examples in nature of a bona fide organometallic bond. Methylcobalamin has been studied in conjunction with sleep-wake rhythm disorders, where it appears to yield benefits, but at a low or inconsistent level. It is used in treating diseases of vitamin B12 deficiency (such as pernicious anemia), or diseases of effective B12 deficiency, such as vitamin B12 metabolic pathway pathologies. One study suggests that once absorbed, methylcobalamin may be retained in the body better than cyanocobalamin.

Pharmacodynamics

Pharmacokinetics

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.


Absorption


Peak plasma concentrations after 3 hr (oral); 0.9 hr (IM); 3 min (IV).


Excretion


Via urine.

Mecobalamin Indications / Mecobalamin Uses

Information Not Available

Mecobalamin Adverse Reactions / Mecobalamin Side Effects

Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site. Potentially Fatal: Anaphylactoid reactions (parenteral).

Precautions

Information Not Available

Special Precautions

Information Not Available

Other Drug Interactions

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Other Interactions

Information Not Available

Dosage

Oral


Peripheral neuropathies Adult: 1500 mcg/day in 3 divided doses.


Parenteral


Peripheral neuropathies Adult: 500 mcg daily IM/IV 3 times/wk.


Parenteral


Megaloblastic anaemia caused by vitamin B12 deficiency Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.

Food(before/after)

May be taken with or without food

List of Contraindications

Mecobalamin and Pregnancy

Not contraindicated

Mecobalamin and Lactation

Not contraindicated

Mecobalamin and Children

Information Not Available

Mecobalamin and Geriatic

Information Not Available

Mecobalamin and Other Contraindications

Information Not Available

Storage

Oral


Store at room temperature. Protect from moisture and light. Parenteral: Store at room temperature. Do not expose to direct light.

Lab interference

Oral


Store at room temperature. Protect from moisture and light. Parenteral: Store at room temperature. Do not expose to direct light.

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