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Dextromethorphan information from DrugsUpdate  

See Available Brands of Dextromethorphan in India

P - Caution when used during pregnancy

Dextromethorphan (DXM or DM) is an antitussive drug. It is one of the active ingredients used to prevent coughs in many over-the-counter cold and cough medicines. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychological applications. It is sold in syrup, tablet, spray, and lozenge forms manufactured under several different brand names and generic labels. In its pure form, dextromethorphan occurs as a white powder.
When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative psychedelic drug. Its mechanism of action is as an NMDA receptor antagonist, producing effects similar to those of the controlled substances ketamine and phencyclidine (PCP).

Pharmacodynamics

Pharmacokinetics

Dextromethorphan, a derivative of levorphanol, is an antitussive agent. It has a central action on the cough center in the medulla.
Onset: Oral: 30 minutes.
Duration: Oral: Up to 6 hr.
Absorption: Rapidly absorbed in the GI tract.
Metabolism: Hepatically metabolised.
Excretion: Excreted in the urine unchanged.

Dextromethorphan Indications / Dextromethorphan Uses

Information Not Available

Dextromethorphan Adverse Reactions / Dextromethorphan Side Effects

Dizziness, GI disturbances

Precautions

Overdosage
Symptoms: In mild overdose, tachycardia, hypertension, vomiting, mydriasis, diaphoresis, nystagmus, euphoria, loss of motor coordination, and giggling; in moderate intoxication, in addition to those listed above, hallucinations and a plodding ataxic gait; in severely intoxication, agitation or somnolence. Management: treatment is symptomatic and supportive. Naloxone may be useful in reversing toxicity.

Special Precautions

Third trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma. Moderate to severe renal impairment; liver disease.

Other Drug Interactions

Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol.
Potentially Fatal: Memantine, moclobemide.

Dosage

Oral
Cough suppressant
Adult: 10-20 mg every 4 hr, or 30 mg every 6-8 hr. Extended-release oral suspension: 60 mg bid. Max: 120 mg/day.
Child: 6-12 yr: 5-10 mg every 4 hr or 15 mg every 6-8 hr; 2-6 yr: 2.5-5 mg every 4 hr or 7.5 mg every 6-8 hr; up to 2 yr: Individualised dosage. Extended release oral suspension: 6-12 yr: 30 mg bid; 2-6 yr: 15 mg bid. Max: 6-12 yr: 60 mg/day; 2-6 yr: 30 mg/day.

Food(before/after)

May be taken with or without food

List of Contraindications

Dextromethorphan and Pregnancy

Caution when used during pregnancy

Dextromethorphan and Lactation

Information Not Available

Dextromethorphan and Children

Information Not Available

Dextromethorphan and Geriatic

Information Not Available

Dextromethorphan and Other Contraindications

Patients at risk of developing resp failure. During an acute attack. Patients receiving MAOI or for 2 wk after discontinuing them. Persistent or chronic cough.

Storage

Oral: Store at 15-30°C.

Lab interference

Oral: Store at 15-30°C.

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