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Desmopressin information from DrugsUpdate  

See Available Brands of Desmopressin in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Desmopressin is a synthetic replacement for vasopressin, the hormone that reduces urine production during sleep. It may be taken nasally, intravenously, or as a pill. Doctors prescribe Desmopressin most frequently for treatment of diabetes insipidus or bedwetting.
In December 2007, US drug regulators banned using desmopressin nasal sprays for treating bedwetting, but said that desmopressin pills are still a safe bedwetting treatment for otherwise healthy patients. The regulators reviewed the drug after two patients using desmopressin nasal sprays died from hyponatremia, an imbalance of sodium levels in the body.

Pharmacodynamics

Pharmacokinetics

Information Not Available

Desmopressin Indications / Desmopressin Uses

Information Not Available

Desmopressin Adverse Reactions / Desmopressin Side Effects

Nausea, transient headache; nasal congestion, rhinitis; flushing; mild abdominal cramps; epistaxis; sore throat, cough, stuffiness; allergic reactions, inj site pain, erythema, swelling, BP changes and thrombotic events in predisposed individuals.
Potentially Fatal: Water intoxication and dilutional hyponatraemia.

Precautions

Information Not Available

Special Precautions

Not to be used in the treatment of Type IIb von Willebrand's disease and nephrogenic diabetes insipidus. Fluid intake restricted to a min and only to satisfy thirst for 8 hr after admin (particularly in the very young and the elderly). Nasal route avoided in patients with nasal mucosal diseases. Caution in CV diseases, oedema states, impairment, hypertension, elderly, cystic fibrosis, fluid and electrolyte imbalance, thrombotic disease; infants and young children. Inj not recommended for infants <3 mth for bleeding disorders. Pregnancy and lactation.

Other Drug Interactions

Drugs that may potentiate antidiuretic effect of desmopressin: chlorpropamide, clofibrate, carbamazepine, fludrocortisone, urea, or TCAs. Drugs that may decrease antidiuretic effect of desmopressin: lithium, heparin, demeclocycline, noradrenaline, and alcohol. Caution when using with other vasopressors.

Other Interactions

Information Not Available

Dosage

Oral
Cranial diabetes insipidus
Adult: Initially, 100 mcg tid adjusted according to response. Maintenance: 100-200 mcg tid, up to 100-1200 mcg daily.
Child: Initially, 100 mcg tid adjusted according to response. Maintenance: 100-200 mcg tid, up to 100-1200 mcg daily.
Oral
Primary nocturnal enuresis
Adult: 200-400 mcg at bedtime.
Child: ≥5 yr: 200-400 mcg at bedtime.
Intravenous
Type I Von Willebrand's disease
Adult: 0.3-0.4 mcg/kg by slow infusion over 15-30 min before surgery.
Intravenous
Testing of fibrinolytic response
Adult: 0.4 mcg/kg infused over 20 min.
Child: 0.4 mcg/kg infused over 20 min.
Parenteral
Cranial diabetes insipidus
Adult: 1-4 mcg daily IM, SC or IV.
Child: 0.4 mcg IM, SC, or IV.
Parenteral
Diagnosis of diabetes insipidus
Adult: 2 mcg as a single dose via SC/IM.
Child: 2 mcg SC/IM.
Parenteral
Renal function testing
Adult: 2 mcg given as SC or IM inj.
Child: Infants: 0.4 mcg; children: 2 mcg. Dose to be given as SC or IM inj.
Nasal
Cranial diabetes insipidus
Adult: 10-40 mcg daily as a single or divided doses.
Child: 3 mth-12 yr: 5-30 mcg daily.
Nasal
Diagnosis of diabetes insipidus
Adult: 20 mcg as a single dose.
Child: 20 mcg as a single dose.
Nasal
Renal function testing
Adult: 40 mcg as a single dose.
Child: 1-15 yr: 20 mcg and infants: 10 mcg. To be given as a single dose.
Nasal
Primary nocturnal enuresis
Adult: 20-40 mcg at bedtime.
Child: ≥5 yr: 20-40 mcg at bedtime.
Nasal
Nocturia associated with multiple sclerosis
Adult: 10-20 mcg at bedtime.
Nasal
Type I Von Willebrand's disease
Adult: 300 mcg; <50 kg: 150 mcg. Should be given within 2 hr before the surgery.

Food(before/after)

May be taken with or without food

List of Contraindications

Desmopressin and Pregnancy

Caution when used during pregnancy.
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Desmopressin and Lactation

Caution when used during lactation

Desmopressin and Children

Information Not Available

Desmopressin and Geriatic

Information Not Available

Desmopressin and Other Contraindications

Hypersensitivity. Impaired renal function (CrCl <50 ml/min). Decompensated cardiac failure with ongoing diuretic treatment.

Storage

Intravenous: Refrigerate at 2-8°C.
Nasal: Refrigerate at 2-8°C.
Oral: Store at 20-25°C.
Parenteral: Refrigerate at 2-8°C.

Lab interference

Intravenous: Refrigerate at 2-8°C.
Nasal: Refrigerate at 2-8°C.
Oral: Store at 20-25°C.
Parenteral: Refrigerate at 2-8°C.

Desmopressin brands in India:

D-Pressin D-Pressin TAB D-Void Des-Press Minirin

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