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Cyproheptadine information from DrugsUpdate  

See Available Brands of Cyproheptadine in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Cyproheptadine usually as cyproheptadine hydrochloride, trade name Periactin) is an antihistaminic/anticholinergic and antiserotonergic agent. It acts as a 5-HT2 receptor antagonist and also blocks calcium channels.

Pharmacodynamics

Pharmacokinetics

Cyproheptadine is a sedating antihistamine with antimuscarinic, serotonin-antagonist and calcium-channel blocking properties. It competes for H1-receptor sites on effector cells in the GIT, blood vessels and resp tract.
Absorption: Absorbed from the GIT (oral).
Metabolism: Completely hepatic.
Excretion: Via urine (as conjugates); via faeces.

Cyproheptadine Indications / Cyproheptadine Uses

Information Not Available

Cyproheptadine Adverse Reactions / Cyproheptadine Side Effects

Slight to moderate drowsiness, fatigue; dry mouth, GI upsets, nausea; appetite increase, wt gain and impaired alertness.

Precautions

General: Cyproheptadine has an atropine-like action and, therefore, should be used with caution in patients with:
History of bronchial asthma
Increased intraocular pressure
Hyperthyroidism
Cardiovascular disease
Hypertension

Special Precautions

Elderly; epilepsy; tasks requiring mental alertness; symptomatic prostate hypertrophy; epilepsy; alcoholism; pregnancy.

Other Drug Interactions

Masks ototoxicity produced by aminoglycosides and antibiotics.
Potentially Fatal: Potentiate CNS depressant actions of alcohol, barbiturates, sedatives, opioid analgesics and neuroleptics. Additive antimuscarinic action with MAOIs, atropine and tricyclic antidepressants.

Other Interactions

Information Not Available

Dosage

Oral
Allergic conditions
Adult: As HCl: 4 mg tid adjusted as necessary. Usual dose range: 12-16 mg daily in 3-4 divided doses. Up to 32 mg daily may be used in some cases.
Child: As HCl: 2-6 yr: 2 mg tid (max: 12 mg daily); 7-14 yr: 4 mg bid-tid (max: 16 mg daily).
Elderly:
Oral
Treatment and prophylaxis of migraine and other vascular headaches
Adult: As HCl: 4 mg, may repeat 30 minutes later. Not to exceed 8 mg within a 4-6-hr period. Maintenance dose: 4 mg every 4-6 hr.

Food(before/after)

May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)

List of Contraindications

Cyproheptadine and Pregnancy

Caution when used during pregnancy.
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters)

Cyproheptadine and Lactation

Contraindicated in lactation

Cyproheptadine and Children

Information Not Available

Cyproheptadine and Geriatic

Information Not Available

Cyproheptadine and Other Contraindications

Narrow-angle glaucoma; acute asthmatic attack; bladder neck obstruction; stenosing peptic ulcer; GIT obstruction; MAOIs therapy; hypersensitivity; neonates, lactation.

Storage

Oral: Store at 15-25°C

Lab interference

Oral: Store at 15-25°C

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