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Cetirizine Hydrochloride information from DrugsUpdate  

See Available Brands of Cetirizine Hydrochloride in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Cetirizine hydrochloride, an antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. The structural similarity of cetirizine to hydroxyzine, and its derivation from piperazine, attribute similar adverse reactions and properties to other piperazine derivatives.

Pharmacodynamics

Pharmacokinetics

Cetirizine is a potent and highly selective antagonist of the peripheral histamine H1-receptor on effector cells in the GI tract, blood vessels and respiratory tract.
Absorption: Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 1 hr. Rate, but not extent, of absorption altered by food.
Distribution: Enters breast milk; crosses the blood-brain barrier (insignificant amounts). Protein-binding: Highly bound.
Excretion: Via the urine (as unchanged); 10 hr (elimination half-life).

Cetirizine Hydrochloride Indications / Cetirizine Hydrochloride Uses

Information Not Available

Cetirizine Hydrochloride Adverse Reactions / Cetirizine Hydrochloride Side Effects

Somnolence, insomnia, malaise, headache, dizziness; GI discomfort, dry mouth, abdominal pain, diarrhoea, nausea, vomiting; occasional hypersensitivity; epistaxis, pharyngitis, bronchospasm.

Precautions

Information Not Available

Special Precautions

Hepatic or renal impairment; elderly; tasks requiring mental alertness eg, driving or operating heavy machinery; pregnancy.

Other Drug Interactions

Risk of increased INR and epistaxis when taken together with warfarin.
Potentially Fatal: CNS depressants and anticholinergics may potentiate CNS depression of cetirizine.

Other Interactions

Information Not Available

Dosage

Oral
Allergic conditions
Adult: 10 mg once daily or 5 mg bid.
Child: 6 mth-2 yr: 2.5 mg once daily (up to 2.5 mg bid in children ≥12 mth) ; 2-5 yr: 5 mg once daily or 2.5 mg bid; >6 yr: 10 mg once daily or 5 mg bid.
Elderly:
Renal impairment: Half the usual dose.
Hepatic impairment: Half the usual dose.

Food(before/after)

Information Not Available

List of Contraindications

Cetirizine Hydrochloride and Pregnancy

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Caution when used during pregnancy.


 

Cetirizine Hydrochloride and Lactation

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Contraindicated in lactation


 

Cetirizine Hydrochloride and Geriatic

Information Not Available

Cetirizine Hydrochloride and Other Contraindications

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Hypersensitivity; lactation


 

Storage

Oral: Store at 20-25°C.
Syr: Can also refrigerate at 2-8°C

Lab interference

Oral: Store at 20-25°C.
Syr: Can also refrigerate at 2-8°C

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