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Ceftizoxime information from DrugsUpdate  

See Available Brands of Ceftizoxime in India

P - Caution when used during pregnancy
L - Caution when used during lactation
LI - Lab*

Ceftizoxime is a parenteral third-generation cephalosporin. Unlike other 3rd generation cephalosporins , in ceftizoxime the whole C-3 side chain has been removed to prevent deactivation by hydrolytic enzymes . It rather resembles Cefotaxime in its properties , however not being subjected to metabolism .

 

Pharmacodynamics

Pharmacokinetics

Ceftizoxime is a parenteral third-generation cephalosporin. Unlike other 3rd generation cephalosporins , in ceftizoxime the whole C-3 side chain has been removed to prevent deactivation by hydrolytic enzymes . It rather resembles Cefotaxime in its properties , however not being subjected to metabolism . Ceftizoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Peak plasma concentrations after 1 hr.
Distribution: Distributed widely into body tissues and fluids; CSF (therapeutic concentrations). Crosses the placenta and enters the breast milk (low concentrations). Protein-binding: 30%
Excretion: Via the urine within 24 hrs by tubular and glomerular filtration (as unchanged); removed by dialysis. 1.7 hrs (elimination half-life).

Ceftizoxime Indications / Ceftizoxime Uses

Information Not Available

Ceftizoxime Adverse Reactions / Ceftizoxime Side Effects

Burning; rash, pruritus, fever; anorexia, nausea, vomiting, diarrhoea; rarely neutropaenia, leucopaenia, thrombocytopaenia. Transient elevations of transaminases (SGOT and SGPT) and alkaline phosphatase, transient rise in BUN and creatinine.
Potentially Fatal: Anaphylactoid reactions, nephrotoxicity, pseudomembranous colitis.

Precautions

Monitor
Response to therapy
Monitor patient's response to therapy. Notify health care provider if infection does not appear to improve or worsens.

Special Precautions

Hypersensitivity to penicillins; severe renal impairment; pregnancy, lactation.

Other Drug Interactions

Renal clearance reduced with probenecid.
Potentially Fatal: Increased risk of nephrotoxicity with aminoglycosides and furosemide.

Other Interactions

Information Not Available

Dosage

Intramuscular
Uncomplicated gonorrhoea
Adult: 1 g as a single dose.
Parenteral
Susceptible infections
Adult: 1-2 g every 8-12 hr given as deep IM or slow IV Inj over 3-5 min, increased to 2-4 g IV every 8 hr in severe infections. Max dose: 2 g every 4 hr.
Child: >6 mth: 50 mg/kg every 6-8 hr.
Renal impairment: Loading dose: 0.5-1 g. Maintenance dose: According to CrCl.

Parenteral
Uncomplicated urinary tract infections
Adult: 0.5 g every 12 hr.
Renal impairment: Loading dose: 0.5-1 g. Maintenance dose: According to CrCl.

Food(before/after)

Information Not Available

List of Contraindications

Ceftizoxime and Pregnancy

Caution when used during pregnancy.
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Ceftizoxime and Lactation

Caution when used during lacttion

Ceftizoxime and Children

Safety and efficacy in infants younger than 6 mo of age not established. In infants, consider benefits relative to risks.

Ceftizoxime and Geriatic

Information Not Available

Ceftizoxime and Other Contraindications

Hypersensitivity to penicillins; severe renal impairment; pregnancy, lactation.

Storage

Intramuscular: Store at 15-30°C.
Parenteral: Store at 15-30°C.

Lab interference

Intramuscular: Store at 15-30°C.
Parenteral: Store at 15-30°C.

Ceftizoxime brands in India:

Cefizox Cureone Eldcef Epocelin T-Zox Traxy Trizox Unizox

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