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Carboprost information from DrugsUpdate  

See Available Brands of Carboprost in India

P - Contraindicated in pregnancy

Carboprost is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α) with oxytocic properties. The trade name of carboprost tromethamine is Hemabate.
Carboprost induces contractions and can trigger abortion in early pregnancy. It also reduces postpartum bleeding. It is used for the treatment of molar pregnancy.
Exert caution in asthmatic patients.

Pharmacodynamics

Pharmacokinetics

Carboprost is a uterine stimulant which results in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental hemostasis.

Carboprost Indications / Carboprost Uses

Information Not Available

Carboprost Adverse Reactions / Carboprost Side Effects

Nausea, vomiting, diarrhoea, abdominal pain, flushing, shivering, headache, dizziness and hypotension, temporary pyrexia, dyspnoea, pulmonary oedema.
Potentially Fatal: Severe CVS disorders including fatal hypotension, tachypnea, pyrexia and MI (in patients with high risk factors) following intra-amniotic or intravaginal admin. Convulsions and ECG changes, amniotic fluid embolism and uterine rupture, foetal distress and rarely foetal death during induction of labour.

Precautions

Information Not Available

Special Precautions

Cardiopulmonary disorders, glaucoma, asthma, epilepsy, severe hepatic or renal dysfunction, labour.

Other Drug Interactions

Action enhanced by prior inj of hyperosmolar urea.
Potentially Fatal: Enhances action of oxytocin hence both drugs should be used sequentially and carefully monitored.

Other Interactions

Information Not Available

Dosage

Intramuscular
Pregnancy termination in the 2nd trimester
Adult: As tromethamine: 250 mcg deep IM, repeated at 1.5 to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if necessary. Max: 12 mg.
Intramuscular
Postpartum haemorrhage
Adult: As tromethamine: 250 mcg deep IM at 15- to 90-min intervals.
Max Dosage: 2 mg.

Food(before/after)

Information Not Available

List of Contraindications

Carboprost and Pregnancy

Contraindicated in pregnancy.
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Carboprost and Lactation

Information Not Available

Carboprost and Children

Information Not Available

Carboprost and Geriatic

Information Not Available

Carboprost and Other Contraindications

Hypersensitivity. Acute pelvic inflammatory disease. Patients with acute cardiac, pulmonary, renal or hepatic disease. History of caesarian, major uterine surgery. Pregnancy.

Storage

Intramuscular: Refrigerate at 2-8°C

Lab interference

Intramuscular: Refrigerate at 2-8°C

Carboprost brands in India:

Deviprost Evacarb Prostodin

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