logo image

Lactulose information from DrugsUpdate  

See Available Brands of Lactulose in India

Lactulose is a synthetic sugar used in the treatment of constipation and hepatic encephalopathy, a complication of liver disease. It is a disaccharide (double-sugar) formed from one molecule each of the simple sugars (monosaccharides) fructose and galactose. The commercial syrup used for treatment of constipation is dyed yellow-orange. It is produced commercially by isomerization of lactose.

Pharmacodynamics

Pharmacokinetics

Lactulose promotes peristalsis by producing an osmotic effect in the colon with resultant distention. In hepatic encephalopathy, it reduces absorption of ammonium ions and toxic nitrogenous compounds, resulting in reduced blood ammonia concentrations. Onset 48 hours.


Absorption Not appreciable (oral).


Metabolism Via colonic flora to lactic acid and acetic acid.


Excretion Faeces, urine (as unchanged drug).

Lactulose Indications / Lactulose Uses

Information Not Available

Lactulose Adverse Reactions / Lactulose Side Effects

Diarrhoea (dose-related), nausea, vomiting, hypokalaemia, bloating and abdominal cramps. Potentially Fatal: Dehydration and hypernatraemia on aggressive treatment.

Precautions

Since Lactulose solution contains galactose (less than 1.6 g/15 mL) and lactose (less than 1.2 g/15 mL), it should be used with caution in diabetics.

Special Precautions

Monitor electrolyte imbalance. Lactose intolerance; diabetics.

Other Drug Interactions

May prevent release of mesalazine in the colon. Decreased effect with oral neomycin, antacids.

Other Interactions

Information Not Available

Dosage

Oral Constipation Adult: Initially, 10-20 g (15-30 ml) daily as a single dose or in 2 divided doses; gradually adjust according to patient's response. Max dose: 45 ml (or up to 40 g of the reconstituted oral powder formulation)/day. Child: As 3.35 mg/5 ml solution: 1 mth to 1 yr: 2.5 ml; 1-5 yr: 5 ml; 5-10 yr: 10 ml; 10-18 yr: 15 ml. All doses to be given bid. Oral Hepatic encephalopathy Adult: 60-100 g (90-150 ml) daily in 3 divided doses; adjust to produce 2 or 3 soft stools each day. Rectal Hepatic encephalopathy Adult: Mix 200 g (300 ml) with 700 ml water or 0.9% sodium chloride as a retention enema. Retain enema for 30-60 minutes; repeat every 4-6 hr until oral medication can be administered.

Food(before/after)

May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)

List of Contraindications

Lactulose and Pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Lactulose and Lactation

Undetermined.

Lactulose and Children

Safety and efficacy not established. Administer with caution. Infants receiving lactulose may develop hyponatremia and dehydration.

Lactulose and Geriatic

With long-term therapy (more than 6 mo) at increased risk of dehydration and electrolyte imbalance.

Lactulose and Other Contraindications

Galactosaemia, intestinal obstruction. Patients on low galactose diet.

Storage

Oral Store at 15-30℃ (59-86°F). Rectal: Store at 2-30℃ (36-86°F).

Lab interference

Oral Store at 15-30℃ (59-86°F). Rectal: Store at 2-30℃ (36-86°F).

© 2011-2018 DrugsUpdate.com. Disclaimer | Site Map

Feedback