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Artesunate information from DrugsUpdate  

See Available Brands of Artesunate in India

P - Cautioned in pregnancy
L - Cautioned in lactation

Artesunate (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.

Pharmacodynamics

Pharmacokinetics

Artesunate is a potent and rapidly-acting blood schizontocide derived from the leaves of the chinese herb, Armesia annua. The exact mode of action is not clear but clinical studies have confirmed the effectiveness of artesunate in P. vivax and falciparum malaria.
Excretion: Elimination half-life: about 45 min after IV admin.

Artesunate Indications / Artesunate Uses

In Falciparum malaria

Artesunate Adverse Reactions / Artesunate Side Effects

Transient and reversible reticulocytopaenia, drug fever, rash, bradycardia, transient 1st-degree heart block and reversible elevation of serum transaminases.

Precautions

Information Not Available

Special Precautions

Hepatic or renal insufficiency. Pregnancy and lactation

Other Drug Interactions

Antimalarial potentiating action seen with mefloquine, primaquine and tetracycline. Additive effect with chloroquine. Antagonistic effect with pyrimethamine and sulphonamides.

Other Interactions

Information Not Available

Dosage

Parenteral
Falciparum malaria
Adult: 2.4 mg/kg via IM or IV admin. Repeat 12 hr and 24 hr later, then once daily thereafter.
Child: 2.4 mg/kg via IM or IV admin. Repeat 12 hr and 24 hr later, then once daily thereafter.

Food(before/after)

Information Not Available

List of Contraindications

Artesunate and Pregnancy

Caution when used during pregnancy

Artesunate and Lactation

Caution when used during lactation

Artesunate and Children

Information Not Available

Artesunate and Geriatic

Information Not Available

Artesunate and Other Contraindications

Hypersensitivity

Storage

Information Not Available

Lab interference

Information Not Available

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