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Artemether information from DrugsUpdate  

See Available Brands of Artemether in India

P - Cautioned in pregnancy
L - Cautioned in lactation

Artemether (INN) is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. It is combined with Lumefantrine and sold by Novartis under the brand names Riamet and Co-Artem.
It is an ether derivative of artemisinin.

Pharmacodynamics

Pharmacokinetics

Special Populations
Renal Function Impairment
No specific pharmacokinetic studies have been performed.
Hepatic Function Impairment
No specific pharmacokinetic studies have been performed.
Elderly
No specific pharmacokinetic studies have been performed in patients older than 65 years of age.
Children
Systemic exposure is comparable with adult patients.
Gender
No clinically relevant effects.

Artemether Indications / Artemether Uses

In acute uncomplicated falciparum malaria

Artemether Adverse Reactions / Artemether Side Effects

Mild GI disturbance, dizziness, tinnitus, reduction in reticulocyte and leucocyte counts, nausea, vomiting, abdominal pain, bradycardia, 1st-degree heart block, transient increase in serum transaminases.

Precautions

Information Not Available

Special Precautions

Pregnancy and lactation. Avoid concomitant use of drugs known to prolong QT interval or monitor such patients.

Other Drug Interactions

Artemether causes QT prolongation in some patients. Thus concomitant use of erythromycin, terfenadine, procainamide, quinidine, disopyramide, amiodarone, bretylium, bepridil, sotalol, astemizole, probucol, tricyclic antidepressants, phenothiazines may be avoided.

Other Interactions

Information Not Available

Dosage

Oral
Acute uncomplicated falciparum malaria
Adult: 80 mg daily, to be taken with lumefantrine 480 mg daily. Doses to be taken at diagnosis and repeated after 8, 24, 36, 48 and 60 hr. Total doses: 6.
Child: Daily doses based on body wt: 5-14 kg: 20 mg with lumefantrine 120 mg; 15-24 kg: 40 mg with lumefantrine 240 mg; 25-34 kg: 60 mg with lumefantrine 360 mg and >34 kg: 80 mg with lumefantrine 480 mg. Doses to be taken at diagnosis and repeated after 8, 24, 36, 48 and 60 hr. Total doses: 6.

Food(before/after)

Should be taken with food

List of Contraindications

Artemether and Pregnancy

Caution when used during pregnancy

Artemether and Lactation

Caution when used during lactation

Artemether and Children

Information Not Available

Artemether and Geriatic

Information Not Available

Artemether and Other Contraindications

Hypersensitivity

Storage

Oral: Store below 30°C

Lab interference

Oral: Store below 30°C

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