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Ampicillin + Cloxacillin information from DrugsUpdate  

3
See Available Brands of Ampicillin + Cloxacillin in India

L - Cautioned in lactation

Ampicillin exerts bactericidal action on both gm+ve and gm-ve organisms. Its spectrum includes gm+ve organisms eg, S pneumoniae and other Streptococci, L monocytogenes and gm-ve bacteria eg, M catarrhalis, N gonorrhoea, N meningitidis, E coli, P mirabilis, Salmonella, Shigella, and H influenzae. Ampicillin exerts its action by inhibiting the synthesis of bacterial cell wall. Cloxacillin is a penicillinase-resistant penicillin. It is active against gm+ve organisms including penicillinase-producing strains of Staphylococci. Cloxacillin is highly active against Staph aureus, Strep pyogenes, Strep viridans and Strep pneumoniae. It is also active against penicillinase-producing gonococci and against N meningitidis and H influenzae. Other gm-ve organisms are resistant to cloxacillin as are also methicillin-resistant strains of Staphylococci.

Pharmacodynamics

Pharmacokinetics

Synergestic action

Ampicillin + Cloxacillin Indications / Ampicillin + Cloxacillin Uses

In moderate to severe infections

Ampicillin + Cloxacillin Adverse Reactions / Ampicillin + Cloxacillin Side Effects

G.I.disturbances, pruritus, urticaria, erythema, exfoliative dermatitis, rashes, fever, joint pain, eosinophilia, bronchial asthma, angioneuratic oedema, hemolytic anaemia, serum sickness, CNS effects like hyperactivity, agitation, insomnia, anxiety, behavioural changes, confusion, dizziness and convulsions.
Potentially Fatal: Anaphylactic reaction.

Precautions

Information Not Available

Special Precautions

Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, history of convulsions, lactation.

Other Drug Interactions

Failure of oral contraceptives, increased rash with allopurinol, reduced bactericidal activity with chloramphenicol, erythromycin and tetracyclines.
Potentially Fatal: NA.

Other Interactions

Food:  Reduced absorption for ampicillin & delayed obsorption for cloxacillin.

Dosage

Oral
Susceptible infections:
Adult- Per Cap contains ampicillin 250mg & Cloxacillin 250mg, one cap four times daily.
In severe infections, the dose can be increased up to 12 caps daily.
Child- Per dose contains ampicillin 125mg, & cloxacillin 125mg: one dose four times daily.

Skin & soft tissue infections osteomyelitis & other bone infections:
Adult- In acute osteomyelitis parenteral therapy for first three weeks for another three weeks in chronic osteomyelitis parenteral therapy for one – two months followed by oral therapy subsequently.

Intravenous:
Severe Infections:
Septicaemia, meningitis endocarditis caused by sensitive pathogens.
Adult- 500mg (Ampicillin 250mg & Cloxacillin 250mg) in ten ml or 1g (ampicillin 500mg & cloxacillin 500mg)
in 20 ml of water for injections. Given slowly over three to four minutes, repeated every six hours.
Doses higher than 500mg should be given in two different sites of not more than 500mg in 3ml.

Food(before/after)

Information Not Available

List of Contraindications

Ampicillin + Cloxacillin and Pregnancy

Information Not Available

Ampicillin + Cloxacillin and Lactation

Caution when used during lactation

Ampicillin + Cloxacillin and Children

Information Not Available

Ampicillin + Cloxacillin and Geriatic

Information Not Available

Ampicillin + Cloxacillin and Other Contraindications

Penicillin allergy

Storage

Information Not Available

Lab interference

Information Not Available

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