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Aminocaproic Acid information from DrugsUpdate  

See Available Brands of Aminocaproic Acid in India

P - Caution when used during pregnancy
L - Caution when used during lactation
LI - Lab*

Aminocaproic acid (also known as Amicar, ε-amino caproic acid, or 6-aminohexanoic acid) is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis. For this reason it is effective in treatment of some bleeding disorders and is marketed as Amicar.

Pharmacodynamics

Pharmacokinetics

Absorption
Oral
Zero order process; absorption rate of 5.2 g/h. C max is about 164 mcg/mL; T max is about 1.2 h.
Distribution
Oral
Vd is about 23.1 L.
IV
Vd is about 30 L.
Metabolism
Metabolite is adipic acid.
Elimination
Renally eliminated. 65% is recovered in the urine as unchanged drug and 11% as the metabolite adipic acid. Renal clearance is 116 mL/min and total body clearance is 169 mL/min. T 1/2 is about 2 h.
Duration
3 h for single IV dose.

Aminocaproic Acid Indications / Aminocaproic Acid Uses

Treatment and prophylaxis of haemorrhage. patients with haemophillia undergoing dental extraction.

Aminocaproic Acid Adverse Reactions / Aminocaproic Acid Side Effects

Cardiovascular: Bradycardia; hypotension; peripheral ischemia; thrombosis.
CNS: Dizziness; headache; delirium; hallucinations; confusion; intracranial hypertension; stroke; syncope.
Dermatologic: Rash; pruritus.
ENT: Tinnitus; decreased vision; watery eyes.
GI: Nausea; diarrhea; abdominal pain; vomiting.
Genitourinary,Increased BUN; renal failure.
Hematologic: Agranulocytosis; coagulation disorder; leukopenia; thrombocytopenia.
Respiratory: Dyspnea; nasal congestion; pulmonary embolism.
Miscellaneous: Injection site reaction; pain and necrosis; myalgia; myositis; myopathy (characterized by muscle weakness, fatigue, elevated creatinine phosphokinase, rhabdomyolysis associated with myoglobinuria and renal failure); edema; allergic and anaphylactic reactions; anaphylaxis; malaise. 

Precautions

Upper urinary tract bleeding.
Not used in treatment of hematuria of upper UT origin unless possible benefits outweigh risks

Special Precautions

Renal or cardiac disorders. Urinary tract bleeding, haematuria of upper urinary tract origin; veno-occlusive hepatic disease, skeletal myopathy, neonates. Monitor creatinine phosphokinase. Avoid admin with factor IX complex concentrates. Pregnancy and lactation.

Other Drug Interactions

Oedema, heacache, malaise, allergic & analphylactic reactiosn, analphlaxis, bradycardia, hypotension peripheral ischaemia, thrombosis, abdominal pain, diarrhoea, anusea, vommiting, agranlocutosis, coagulation disorder, leukopaenia, thrombocytopaenia, increased CPK, muscle damage, myalgia, mypopathy, myositis, rhabdomyolysis, confusion, convulsions, derilium, dizziness, hallucinations, intracranial hypertension, stroke, syncope, dysponea, nasal congestion, pulmonary embolism, pruritus, rash, tinnitus, decreased vision, watery eyes, increased BUN, dry ejaculation. Cardiac & hepatic damage.

Other Interactions

Information Not Available

Dosage

Oral
Treatment and prophylaxis of haemorrhage

Adult- Initially, 4-5 g, followed by 1-1.25 g every hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr.
Renal impairment: Dosage reduction may be required.

Oral

Patients with haemophilia undergoing dental extraction

Adult- Initially, 6 g immediately after the procedure, followed by 6 g every 6 hour for up to 10 days.

Intravenous

Treatment and prophylaxis of haemorrhage
Adult- Initially, 4-5 g as a 2% solution over 1 hr followed by a 1 g/hr infusion continued for up to 8 hr or until bleeding has been controlled. Max: 24 g in 24 hour.

Renal impairment: Dosage reduction may be required.

Food(before/after)

May be taken with or without food. (May be taken w/ meals to prevent GI upset.

List of Contraindications

Aminocaproic Acid and Pregnancy

Caution when used during pregnancy

Aminocaproic Acid and Lactation

Caution when used during lactation

Aminocaproic Acid and Children

Information Not Available

Aminocaproic Acid and Geriatic

For aminocaproic acid : Although there is no specific information comparing use of aminocaproic acid in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Aminocaproic Acid and Other Contraindications

Bleeding due to disseminated intravascular coagulation. Rapid IV administration.

Storage

Intravenous: Store at 15-30°C

Lab interference

Intravenous: Store at 15-30°C

Aminocaproic Acid brands in India:

Amocap Hamostat Hemocid

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