Drugsupdate.com is up for sale. To own one of the most recognized online brands by doctors in India with millions of visitors - click here.

logo image

Abacavir Sulfate information from DrugsUpdate  

See Available Brands of Abacavir Sulfate in India

P - Contraindicated in pregnancy
L - Caution when used during lactation

Abacavir is a nucleoside analog which inhibits reverse transcriptase enzyme and interferes with DNA synthesis mainly used to treat HIV and AIDS.

Pharmacokinetics

Abacavir is converted to the active form carbovir triphosphate intracellularly. It competitively inhibits the reverse transcriptase of retroviruses interfering with HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication.


Absorption


Rapidly and extensively absorbed. Bioavailability is 83% (tablets).


Distribution:


50% bound to plasma proteins.


Metabolism


Metabolized to inactive metabolites by alcohol dehydrogenase and glucuronyl transferase.


Elimination


1.2% is excreted in the urine as abacavir; 81% as inactive metabolites; 16% is excreted in the feces. The half-life is approximately 1.54 hour.


 

Abacavir Sulfate Indications / Abacavir Sulfate Uses

Information not available.

Abacavir Sulfate Adverse Reactions / Abacavir Sulfate Side Effects

Mainly hypersensitivity reactions symptoms include fever, skin rash, fatigue; gastrointestinal symptoms such as nausea, vomiting, diarrhea or abdominal pain and respiratory symptoms such as pharyngitis, dyspnea or cough.

Precautions

Overdosage
May result in acute renal failure with rhabdomyolysis, coma and seizures.

Special Precautions

Special Precautions
Recovery after MI, elderly, CVS disease, liver impairment, epilepsy, psychosis, increased intraocular pressure, history of urinary retention, alcohol, pregnancy and lactation; avoid abrupt withdrawal.

Other Drug Interactions

Alcohol may cause decreased elimination of abacavir. Lactic acidosis with nucleoside analogues concomitantly. Decreased serum concentrations of methadone.

Other Interactions

Drinking alcoholic beverages increases the level of abacavir in the blood, perhaps increasing the risk of side effects.

Dosage

Adults


PO 600 mg once daily or 300 mg twice daily in combination with other antiretroviral agents.


Adolescents and Children


PO 8 mg/kg twice daily (max, 300 mg twice daily) in combination with other antiretroviral agent


Hepatic Impairment
PO 200 mg twice daily in patients with mild hepatic function impairment.

Food(before/after)

May be taken with or without food.

List of Contraindications

Abacavir Sulfate and Pregnancy

Contraindicated in pregnancy.

Abacavir Sulfate and Lactation

It is not known whether abacavir passes into breast milk. However, because of the possibility that this medicine could cause unwanted effects in nursing babies and the risk of passing HIV on to the infant, breast-feeding is not recommended.

Abacavir Sulfate and Children

Safety and efficacy not established in children younger than 3 months of age.

Abacavir Sulfate and Geriatic

There is no specific information comparing use of abacavir in the elderly with use in other age groups.

Abacavir Sulfate and Other Contraindications

Moderate or severe hepatic function impairment; hypersensitivity to any component of the product.

Storage

Store at 20-25°C. Solution may be refrigerated, but do not freeze.

Lab interference

Store at 20-25°C. Solution may be refrigerated, but do not freeze.

Abacavir Sulfate brands in India:

Abamune Abec Synabac Virol Ziagen

© 2011-2018 DrugsUpdate.com. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.