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Dutasteride + Tamsulosin information from DrugsUpdate  

See Available Brands of Dutasteride + Tamsulosin in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation
FI - Food *
LI - Lab *

Information Not Available

Pharmacodynamics

Pharmacokinetics

Tamsulosin is a selective α-1 adrenoceptor blocker. It blocks α-1 adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck, resulting relaxation of these adrenoceptors in the bladder neck and prostate. Thus, there is an improvement in urine flow rate and reduction in symptoms of benign prostatic hypertrophy (BPH). Dutasteride inhibits 5 α-reductase, the enzyme responsible for conversion of testosterone to 5α-dihydrotestosterone (DHT). DHT appears to be the principal androgen responsible for stimulation of prostatic growth.

Dutasteride + Tamsulosin Indications / Dutasteride + Tamsulosin Uses

Information Not Available

Dutasteride + Tamsulosin Adverse Reactions / Dutasteride + Tamsulosin Side Effects

Impotence, decreased libido, ejaculation disorders, breast tenderness and enlargement, postural hypotension, dizziness and vertigo, headache, infection, asthenia, back pain, chest pain, somnolence, insomnia, rhinitis, pharyngitis, cough, sinusitis, diarrhoea, nausea, tooth disorder, blurred vision.

Precautions

Information Not Available

Special Precautions

Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling leaking capsules of dutasteride. Prostate carcinoma should be ruled out before starting the therapy. Blood donation to be avoided during and at least 6 months after discontinuance of drug.

Other Drug Interactions

Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases tamsulosin serum concentration; increase in blood concentrations of dutasteride in the presence of inhibitors of CYP3A4/5 such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, troleandomycin, and ciprofloxacin.

Other Interactions

Food Interactions
Food prolongs time to reach max concentration.

Dosage

Oral
Benign prostatic hyperplasia
Adult: Per tab contains tamsulosin 0.4 mg and dutasteride 0.5 mg: 1 tablet once daily.

Food(before/after)

Information Not Available

List of Contraindications

Dutasteride + Tamsulosin and Pregnancy

Contraindicated in pregnancy

Dutasteride + Tamsulosin and Lactation

Contraindicated in lactation

Dutasteride + Tamsulosin and Children

Information Not Available

Dutasteride + Tamsulosin and Geriatic

Information Not Available

Dutasteride + Tamsulosin and Other Contraindications

Hypersensitivity, severe liver impairment. Pregnancy, lactation, child, adolescent.

Storage

Information Not Available

Lab interference

Information Not Available

Dutasteride + Tamsulosin brands in India:

Dutas-T Tamdura Tamlocept D Veltam Plus

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