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Cefotaxime + Sulbactam information from DrugsUpdate  

See Available Brands of Cefotaxime + Sulbactam in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Information Not Available

Pharmacodynamics

Pharmacokinetics

Cefotaxime is a bactericidal drug, which inhibits the bacterial wall synthesis of the actively dividing cells by binding to one or more penicillin-binding proteins. Sulbactam is a semisynthetic β-lactam sulphone, which inhibits β-lactamases of the Richmond types II, III, IV and V (plasmid or chromosomally mediated). This inhibition is reported to be both reversible and irreversible. It acts as a suicide inhibitor by forming a reversible inactive enzyme-sulbactam complex. This reversible acyl-intermediate may then revert to a more stable complex, which irreversibly inhibits the β-lactamase. Sulbactam is able to protect the activity of various β-lactam antibiotics by rendering β-lactamases inactive.

Cefotaxime + Sulbactam Indications / Cefotaxime + Sulbactam Uses

Information Not Available

Cefotaxime + Sulbactam Adverse Reactions / Cefotaxime + Sulbactam Side Effects

Local reactions including pain at the Injection site and phloebitis.


Others: Skin rash, diarrhoea, nausea, vomiting and colitis.

Precautions

Information Not Available

Special Precautions

Previous hypersensitivity to penicillins or other drugs; patients with renal insufficiency; history of GI disease, especially colitis. Pregnancy and lactation.

Other Drug Interactions

Concomitant admin of cephalosporins and aminoglycoside antibiotics

Other Interactions

Information Not Available

Dosage

Oral
Genito-urinary infections, Lower respiratory tract infections
Adult: Mild to moderate infections: 1/0.5 g to 2/1 g of cefotaxime/sulbactam every 8-12 hours.
Moderate to severe infections: 1/0.5 g to 2/1 g of cefotaxime/sulbactam every 6-8 hours.
Child: 100/50 mg to 150/75 mg of cefotaxime/sulbactam /kg/day in 3 divided doses. Life-threatening infections: Dose of cefotaxime may be increased up to 12 g/day.

Max Dosage: Sulbactam: Adult: 4 g. Child: 80 mg/kg/day in divided doses.

Renal impairment: Dose adjustment may be needed.

Food(before/after)

Information Not Available

List of Contraindications

Cefotaxime + Sulbactam and Pregnancy

Caution when used during pregnancy

Cefotaxime + Sulbactam and Lactation

Caution when used during lactation

Cefotaxime + Sulbactam and Children

Information Not Available

Cefotaxime + Sulbactam and Geriatic

Information Not Available

Cefotaxime + Sulbactam and Other Contraindications

Hypersensitivity to cefotaxime, sulbactam or the combination

Storage

Information Not Available

Lab interference

Information Not Available

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