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Pantoprazole + Domperidone information from DrugsUpdate  

See Available Brands of Pantoprazole + Domperidone in India

P - Contraindicated in pregnancy
L - Caution when used during lactation

The combination of domperidone and pantoprazole is marketed as Dompan by Medley Pharmaceuticals.

Pharmacodynamics

Pharmacokinetics

Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.

Pantoprazole + Domperidone Indications / Pantoprazole + Domperidone Uses

Information Not Available

Pantoprazole + Domperidone Adverse Reactions / Pantoprazole + Domperidone Side Effects

Pantoprazole: Diarrhoea, dizziness, pruritus, skin rashes, GIT infections; anaphylaxis, angioedema, chest pain, dyspnoea, erythema multiforme, gastroenteritis, hyperglycaemia, infection, Inj site reaction, jaundice, optic neuropathy, anterior ischaemia, pancreatitis, speech disorder. Domperidone: Headache, insomnia, nervousness, dizziness, thirst, lethargy, irritability, GI disturbances, hot flushes, mastalgia, galactorrhoea, gynaecomastia, menstrual irregularities, rash, pruritus, urticaria, stomatitis, conjunctivitis, urinary frequency, dysuria, oedema, palpitations, leg cramps, asthaenia, drug intolerance.

Precautions

Information Not Available

Special Precautions

Lactation. Pantoprazole: Not recommended in child <12 years. Long-term therapy may lead to bacterial overgrowth in the GIT. Domperidone: Increases serum prolactin levels resulting to galactorrhoea in females and gynaecomastia in males. Hypertensive crisis in patients with phaeochromocytoma.

Other Drug Interactions

Care should be exercised when domperidone is administered in combination with MAO inhibitors.

Other Interactions

Information Not Available

Dosage

Oral
Gastro-oesophageal reflux disease, Dyspepsia
Adult: Per tablet/capsule contains pantoprazole 40 mg and domperidone 10 mg: 1 tablet/capsule once daily.

Food(before/after)

Information Not Available

List of Contraindications

Pantoprazole + Domperidone and Pregnancy

Contraindicated in pregnancy

Pantoprazole + Domperidone and Lactation

Caution when used during lactation

Pantoprazole + Domperidone and Children

Information Not Available

Pantoprazole + Domperidone and Geriatic

Information Not Available

Pantoprazole + Domperidone and Other Contraindications

Pantoprazole: Hepatic impairment; hypersensitivity. Domperidone: History of hypersensitivity to dimenhydrinate or related compounds; GI haemorrhage, obstruction and perforation, or after surgery, pregnancy

Storage

Information Not Available

Lab interference

Information Not Available

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