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Cefadroxil information from DrugsUpdate  

See Available Brands of Cefadroxil in India

P - Caution when used during pregnancy
L - Caution when used during lactation
LI - Lab*

Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic.

Pharmacodynamics

Pharmacokinetics

Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.

Absorption
Well absorbed from the GI tract (oral); peak plasma concentrations after 1.5-2 hours.

Distribution
Body tissues and fluids (wide); crosses the placenta and enters breast milk. Protein-binding: 20%.

Excretion
Via urine by glomerular filtration and tubular secretion (90% as unchanged); 1.5 hours (elimination half-life), prolonged in renal impairment. Removed by dialysis.

Cefadroxil Indications / Cefadroxil Uses

Information Not Available

Cefadroxil Adverse Reactions / Cefadroxil Side Effects

Nausea, vomiting, diarrhoea, abdominal discomfort; skin rash, angioedema; elevated liver enzyme values; superinfection with resistant organisms especially candida.

Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Precautions

Monitor
Response to therapy
Monitor patient's response to therapy. Notify health care provider if infection does not improve or appears to worsen.

Side effects
Monitor patient for GI, DERM, and general body side effects, and signs of superinfection. Inform health care provider if noted and significant. Immediately report severe diarrhea, diarrhea containing blood or pus, or severe abdominal cramping.

Special Precautions

Impaired renal function; pregnancy and lactation.

Other Drug Interactions

Prothrombin time prolonged; bleeding may occur when taken with anticoagulants. Decreased elimination with probenecid.

Other Interactions

Information Not Available

Dosage

Oral
Uncomplicated lower urinary tract infections
Adult: 1-2 g daily as a single or 2 divided doses.
Child: >6 years: 500 mg bid; 1-6 years: 250 mg bid; <1 year: 25 mg/kg daily in divided doses.
CrCl (ml/min)    Dosage Recommendation
26-50               0.5-1 g bid.
11-25               0.5-1 g once daily.
≤10                  0.5-1 g every 36 hours.

Oral
Skin and skin structure infections
Adult: 1 g/day in single or divided doses.
Child: 30 mg/kg/day in equally divided doses every 12 hours.
CrCl (ml/min)    Dosage Recommendation
26-50               0.5-1 g bid.
11-25               0.5-1 g once daily.
≤10                  0.5-1 g every 36 hours.

Oral
Pharyngitis
Adult: For treatment of group A β-haemolytic streptococcal pharyngitis and tonsillitis: 1 g/day in single or divided doses for 10 days.
Child: 30 mg/kg/day in equally divided doses every 12 hours for at least 10 days.
CrCl (ml/min)    Dosage Recommendation
26-50               0.5-1 g bid.
11-25               0.5-1 g once daily.
≤10                  0.5-1 g every 36 hours.

Oral
Tonsillitis
Adult: For treatment of group A β-haemolytic streptococcal pharyngitis and tonsillitis: 1 g/day in single or divided doses for 10 days.
Child: 30 mg/kg/day in equally divided doses every 12 hours for at least 10 days.
CrCl (ml/min)    Dosage Recommendation
26-50               0.5-1 g bid.
11-25               0.5-1 g once daily.
≤10                  0.5-1 g every 36 hours.

Food(before/after)

May be taken with or without food. (May be taken with meals to reduce GI discomfort.)

List of Contraindications

Cefadroxil and Pregnancy

Caution when used during pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Cefadroxil and Lactation

Caution when used during lactation

Cefadroxil and Children

In infants, consider benefits relative to risks. Drug may accumulate in newborns.

Cefadroxil and Geriatic

Information Not Available

Cefadroxil and Other Contraindications

Hypersensitivity to cephalosporins

Storage

Oral
Store at 15-30°C.

Lab interference

Oral
Store at 15-30°C.

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