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Doxylamine + Pyridoxine information from DrugsUpdate  

See Available Brands of Doxylamine + Pyridoxine in India

L - Caution when used during lactation

Doxylamine succinate is one of the many sedating antihistamines used by itself as a short-term sedative, in combination with other drugs as a night-time cold and allergy relief drug, in combination with the analgesics paracetamol (acetaminophen) and codeine as an analgesic/calmative preparation, and is prescribed in combination with vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.

Pharmacodynamics

Pharmacokinetics

Doxylamine is an antihistamine derived from monoethanolamine possessing antimuscarinic and pronounced sedative effects. Pyridoxine is a precursor of pyridoxal, which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.

Doxylamine + Pyridoxine Indications / Doxylamine + Pyridoxine Uses

Information Not Available

Doxylamine + Pyridoxine Adverse Reactions / Doxylamine + Pyridoxine Side Effects

Acute dystonic reactions and long-lasting impaired consciousness in child. CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, extrapyramidal effects, tremor, confusion, tinnitus, hypotension, hair loss. Severe peripheral neuropathies with long-term admin of large doses of pyridoxine.

Precautions

Information Not Available

Special Precautions

May impair ability to drive and operate machinery. Angle-closure glaucoma, urinary retention, prostatic hypertrophy or pyloroduodenal obstruction; epilepsy; hepatic impairment, elderly. Lactation.

Other Drug Interactions

Doxylamine enhances effects of CNS depressants eg alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Atropine, tricyclic antidepressants (TCAs), MAOIs. It can mask signs of ototoxicity caused by aminoglycosides. INH, penicillamine and OC require greater pyridoxine dose. Pyridoxine reduces the effects of levodopa, phenobarb and phenytoin.

Other Interactions

Information Not Available

Dosage

Oral
Pregnancy-associated nausea and vomiting
Adult: Each tab contains doxylamine 10 mg and pyridoxine 10 mg: 2 tab at bedtime. In severe cases or in cases with nausea/vomiting during the day: increase dosage by 1 tab in morning and/or afternoon.

Food(before/after)

Information Not Available

List of Contraindications

Doxylamine + Pyridoxine and Pregnancy

Information Not Available

Doxylamine + Pyridoxine and Lactation

Caution when used during lactation

Doxylamine + Pyridoxine and Children

Information Not Available

Doxylamine + Pyridoxine and Geriatic

Information Not Available

Doxylamine + Pyridoxine and Other Contraindications

Severe liver disease; avoid alcohol; premature infants or full-term neonates

Storage

Information Not Available

Lab interference

Information Not Available

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