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Dimenhydrinate information from DrugsUpdate  

See Available Brands of Dimenhydrinate in India

P - Caution when used during pregnancy
L - Contraindicated in lactation
LI - Lab*

Dimenhydrinate is an over-the-counter drug used to prevent nausea and motion sickness. It is most commonly used as pills, although it is also available in liquid form and in suppositories. This last is particularly useful in the case of persistent vomiting.

Pharmacodynamics

Pharmacokinetics

Dimenhydrinate is an antihistamine which also has antimuscarinic and central sedative action. It also exerts a depressant action on hyperstimulated labyrinthine function.

Dimenhydrinate Indications / Dimenhydrinate Uses

Information Not Available

Dimenhydrinate Adverse Reactions / Dimenhydrinate Side Effects

Sedation, dry mouth, thickened respiratory tract secretions, tightness of chest, bradycardia followed by tachycardia and arrhythmias, blurred vision, urinary retention, constipation, GI disturbance, blood dyscrasias. Paradoxical CNS stimulation may occur in children and occasionally in adults.

Precautions

Monitor
Take safety precautions if drowsiness or dizziness occurs. Note paradoxical effect occurs (eg, insomnia, CNS stimulation), and visual or auditory disturbances (eg, blurred vision/tinnitus, hearing loss).

Overdosage
Symptoms in children: dilated pupils, flushed face, excitation, hallucinations, confusion, ataxia, intermittent clonic convulsions, coma, cardiorespiratory collapse, and death. Symptoms may manifest up to 2 hours after ingestion and death may occur within 18 hours. Symptoms in adult: Difficulty in speech and swallowing, psychosis, sedation then CNS excitation, leading to a cycle of CNS excitation, seizures and postictal depression. Mangagement: Treatment is symptomatic and supportive. Gastric lavage may be performed with an endotracheal tube with cuff inflated in place to prevent aspiration of gastric contents. Keep patient quiet to reduce CNS stimulation. Convulsions may be treated with diazepam in adults and phenobarbital in children.

Special Precautions

Angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction, epilepsy. Elderly. Tasks requiring mental alertness. Pregnancy.

Other Drug Interactions

Physically incompatible with aminophylline, hydrocortisone, phenothiazines and some barbiturates in solution.

Potentially Fatal: Potentiates the sedative effects of CNS depressants including alcohol, barbiturates, opioid analgesics, sedatives and neuroleptics. MAOIs, atropine, TCAs enhance antimuscarinic effect. Masks ototoxicity produced by aminoglycoside antibiotics.

Other Interactions

Information Not Available

Dosage

Oral
Treatment and prophylaxis of motion sickness
Adult: 50-100 mg 3-4 times daily. For prevention of motion sickness, 1st dose to be given at least 30 minutes before traveling.
Child: 2-6 years: 12.5-25 mg; 6-12 years: 25-50 mg; Doses can be repeated every 6-8 hours. Max: 75 mg daily (2-6 years) and 150 mg daily (6-12 years).

Oral

Nausea and vertigo caused by Meniere's disease
Adult: 50-100 mg 3-4 times daily. For prevention of motion sickness, 1st dose to be given at least 30 minutes before traveling.
Child: 2-6 years: 12.5-25 mg; 6-12 years: 25-50 mg; Doses can be repeated every 6-8 hours. Max: 75 mg daily (2-6 years) and 150 mg daily (6-12 years).

Parenteral
Treatment and prophylaxis of motion sickness
Adult: 50 mg in a 5% solution given IM or 0.5% slow IV injection given over 2 minutes.
Child: 1.25 mg/kg IM or slow IV injection 4 times daily. Max: 300 mg/day.

Parenteral
Nausea and vertigo caused by Meniere's disease
Adult: 50 mg in a 5% solution given IM or 0.5% slow IV inj given over 2 minutes.
Child: 1.25 mg/kg IM or slow IV injection 4 times daily. Max: 300 mg/day.

Food(before/after)

May be taken with or without food

List of Contraindications

Dimenhydrinate and Pregnancy

Caution when used during pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Dimenhydrinate and Lactation

Contraindicated in lactation

Dimenhydrinate and Children

Safety and efficacy in children younger than 2 years of age not established.

Dimenhydrinate and Geriatic

Information Not Available

Dimenhydrinate and Other Contraindications

Hypersensitivity to dimenhydrinate, porphyria. Neonates. Lactation.

Storage

Oral
Store below 25°C.

Parenteral

Store below 25°C.

Lab interference

Oral
Store below 25°C.

Parenteral

Store below 25°C.

Dimenhydrinate brands in India:

Dramamine Draminate Gravol

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