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Cefixime information from DrugsUpdate  

See Available Brands of Cefixime in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food*
LI - Lab*

Cefixime is an oral third generation cephalosporin antibiotic. It is used to treat gonorrhea, tonsilitis, and pharyngitis. The usual dose is 400 mg in two divided doses for up to 5-7 days.

In India it is available under brand names, such as, SECEF (Novartis ), Zeefix (Agio Pharmaceuticals Ltd.);Cefigard 50DT, 100DT, 200DT, Dry syrup(Vanguard therapetics Pvt Ltd), Ceftas-200 (Intas Pharmaceuticals); ZiFi CV-200 (FDC Limited) Alfi (Alkem Laboratories).



Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Only 40-50% is absorbed from the GI tract (oral); rate may be decreased if taken with food. Greater absorption from oral suspension than tablets.

Bile, urine (high concentrations); crosses the placenta. Protein-binding: 65%.

20% of an oral dose excreted via urine unchanged; 60% nonrenal elimination; some is excreted via the faeces from the bile. Substantially removed by dialysis.

Cefixime Indications / Cefixime Uses

Information Not Available

Cefixime Adverse Reactions / Cefixime Side Effects

Diarrhoea, nausea, vomiting, abdominal pain; headache, dizziness, thrombocytopenia, eosinophilia.

Potentially Fatal: Pseudomembranous colitis.


Monitor PT and patient's response to therapy.

Adverse reactions
Monitor patient for GI, CNS, general body adverse reactions, and signs of superinfection.

Special Precautions

History of allergy to penicillins; pregnancy, lactation; renal failure; GI disease.

Other Drug Interactions

Increased concentrations with probenecid.

Potentially Fatal: May increase prothrombin time with anticoagulants.

Other Interactions

Food Interaction
Absorption delayed in the presence of food.


Susceptible infections
Adult: 200-400 mg/day as a single dose or in 2 divided doses.
Child: 8 mg/kg/day as a single dose or in 2 divided doses; <6 months: Not recommended. Treatment should be continued for 48 hours after disappearance of symptoms.
Renal impairment:     Dose reduction is necessary.
CrCl (ml/min)            Dosage Recommendation
<20                          Max: 200 mg daily.

Uncomplicated gonorrhoea
Adult: 400 mg as a single dose.
Renal impairment: Dose reduction is necessary.
CrCl (ml/min)           Dosage Recommendation
<20                         Max: 200 mg daily.


Should be taken with food.

List of Contraindications

Cefixime and Pregnancy

Caution when used during pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Cefixime and Lactation

Caution when used during lactation

Cefixime and Children

Safety and efficacy not established in children younger than 6 mo of age.

Cefixime and Geriatic

Information Not Available

Cefixime and Other Contraindications

Hypersensitivity to cephalosporin


Store below 25°C.

Lab interference

Store below 25°C.

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