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Diacerein information from DrugsUpdate  

See Available Brands of Diacerein in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Diacerein, also known as diacetylrhein, is a drug used in the treatment of osteoarthritis. It works by inhibiting interleukin-1.

Pharmacodynamics

Pharmacokinetics

Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1β.

Diacerein Indications / Diacerein Uses

Information Not Available

Diacerein Adverse Reactions / Diacerein Side Effects

Diarrhoea, epigastric pain, nausea, vomiting, intense yellow colouring of urine.

Precautions

Information Not Available

Special Precautions

Renal impairment. Monitor CBC, LFT and urinalysis every 6 months.

Other Drug Interactions

Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates.

Other Interactions

Information Not Available

Dosage

Oral
Osteoarthritis
Adult: 50 mg bid.
CrCl (ml/min)    Dosage Recommendation
<30                  25 mg daily.

Food(before/after)

Should be taken with food. (Take with or immediately after meals.)

List of Contraindications

Diacerein and Pregnancy

Contraindicated in pregnancy

Diacerein and Lactation

Contraindicated in lactation

Diacerein and Children

Information Not Available

Diacerein and Geriatic

Information Not Available

Diacerein and Other Contraindications

Pregnancy, lactation. Hypersensitivity to anthraquinone derivatives.

Storage

Oral
Store at 15-25°C.

Lab interference

Oral
Store at 15-25°C.

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