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Glimepiride + Metformin information from DrugsUpdate  

See Available Brands of Glimepiride + Metformin in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Information Not Available

Pharmacodynamics

Pharmacokinetics

Glimepiride stimulates the insulin release from functioning pancreatic β-cells and inhibits gluconeogenesis at hepatic cells. It also increases insulin sensitivity at peripheral target sites. Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).

Glimepiride + Metformin Indications / Glimepiride + Metformin Uses

Information Not Available

Glimepiride + Metformin Adverse Reactions / Glimepiride + Metformin Side Effects

Diarrhoea, vomiting, metallic taste, rash, isolated transaminase elevations, cholestatic jaundice, allergic skin reactions, photosensitivity reactions, leukopaenia, agranulocytosis, thrombocytopaenia, haemolytic anaemia, aplastic anaemia, pancytopaenia, blurred vision.

Potentially Fatal: Lactic acidosis.

Precautions

Information Not Available

Special Precautions

Renal and hepatic impairment. Avoid alcohol consumption. Hypoglycaemic episodes.

Other Drug Interactions

Concomitant admin with propranolol increases Cmax, AUC, and T1/2 of glimepiride. Aspirin increases the mean AUC of glimepiride. Furosemide increases the Cmax of metformin.

Potentially Fatal: NSAIDS, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, MAOs, and beta blockers potentiate the hypoglycemic action of glimepiride.

Other Interactions

Information Not Available

Dosage

Oral
Type 2 diabetes mellitus
Adult: Per tablet contains glimepiride 1 mg and metformin 250 mg or glimepiride 2 mg and metformin 500 mg: Take as directed. Titrate according to response.

Food(before/after)

Information Not Available

List of Contraindications

Glimepiride + Metformin and Pregnancy

Contraindicated in pregnancy

Glimepiride + Metformin and Lactation

Contraindicated in lactation

Glimepiride + Metformin and Children

Information Not Available

Glimepiride + Metformin and Geriatic

Information Not Available

Glimepiride + Metformin and Other Contraindications

Hypersensitivity diabetic ketoacidosis (DKA); renal dysfunction; CHF (CHF), patients undergoing radiological studies; acute or chronic metabolic acidosis. Pregnancy, lactation.

Storage

Information Not Available

Lab interference

Information Not Available

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