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Clotrimazole information from DrugsUpdate  

See Available Brands of Clotrimazole in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.

Pharmacodynamics

Pharmacokinetics

Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.


Absorption
Negligible through intact skin (topical); 3-10% (vaginal).

Metabolism
Hepatic; converted to inactive metabolites.

Excretion
Urine, faeces (as metabolites).

Clotrimazole Indications / Clotrimazole Uses

Information Not Available

Clotrimazole Adverse Reactions / Clotrimazole Side Effects

Topical
Erythema, stinging, irritation; hypersensitivity reactions; contact dermatitis.

Oral
GI disturbances, dysuria, mental depression, elevated liver enzymes.

Precautions

General
If irritation or sensitivity develops with the use of Clotrimazole, treatment should be discontinued and appropriate therapy instituted.

Special Precautions

Avoid contact with eyes upon topical application. Children <3 years. Pregnancy, lactation.

Other Drug Interactions

Antagonism with polyene antibiotics

Other Interactions

Information Not Available

Dosage

Oral
Oropharyngeal candidiasis
Adult: Per lozenge contains 10 mg clotrimazole: Suck 1 lozenge 5 times daily for 14 days.
For prevention in patients receiving immunosuppressant therapy: 1 lozenge tid for the immunosuppressant treatment duration.

Vaginal
Vulvovaginal candidiasis
Adult: As pessary: 100 mg daily for 6 days, 200 mg daily for 3 days or 500 mg as a single dose; alternatively, apply 1, 2 or 10% cream.

Otic/Aural
Fungal otitis externa
Adult: Apply 1% solution to affected area.

Topical/Cutaneous
Skin fungal infections
Adult: Apply a 1% cream/lotion/solution bid-tid for 2-4 weeks, may be used with a 1% powder to prevent reinfection.

Food(before/after)

Information Not Available

List of Contraindications

Clotrimazole and Pregnancy

Caution when used during pregnancy

Clotrimazole and Lactation

Caution when used during lactation

Clotrimazole and Children

Information Not Available

Clotrimazole and Geriatic

Information Not Available

Clotrimazole and Other Contraindications

Hypersensitivity

Storage

Oral
Store below 30°C.

Otic/Aural
Store below 30°C.

Topical/Cutaneous

Store below 30°C.

Vaginal
Store below 30°C.

Lab interference

Oral
Store below 30°C.

Otic/Aural
Store below 30°C.

Topical/Cutaneous

Store below 30°C.

Vaginal
Store below 30°C.

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