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Vitamin D3 + Calcium Carbonate information from DrugsUpdate  

See Available Brands of Vitamin D3 + Calcium Carbonate in India

FI - Food*

Information Not Available

Pharmacodynamics

Pharmacokinetics

Calcium carbonate is a calcium supplement that is used in deficiency states and as an adjunct in the prevention and treatment of osteoporosis. Vitamin D3 is a fat-soluble sterol, it aids in the regulation of calcium and phosphate homeostasis and bone mineralisation.

Absorption
Calcium carbonate: About 15-25% gets absorbed in the GI tract. Converted to calcium chloride by gastric acid. Vitamin D: Well-absorbed in the GI tract in the presence of bile.

Metabolism

Vitamin D: Undergoes hydroxylation in the liver and kidney to form the active metabolite, 1,25-dihydrocolecalciferol.

Excretion
Vitamin D and metabolites are mainly excreted in the bile and faeces.

Vitamin D3 + Calcium Carbonate Indications / Vitamin D3 + Calcium Carbonate Uses

Information Not Available

Vitamin D3 + Calcium Carbonate Adverse Reactions / Vitamin D3 + Calcium Carbonate Side Effects

Constipation, flatulence, nausea, abdominal pain and diarrhoea. Pruritus, rash and urticaria.

Precautions

Information Not Available

Special Precautions

Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients receiving high doses of vitamin D. Caution when using in patients with history of kidney stones. Renal impairment; frequent monitoring of serum calcium and phosphorus is recommended.

Other Drug Interactions

May affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Concurrent use with ion-exchange resins may reduce GI absorption of vitamin D. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, monitor ECG and serum calcium levels. Bisphosphonate or sodium fluoride should be given at least 3 hours before calcium-containing preparations.

Other Interactions

Food Interaction
Foods that are rich in oxalic acid (e.g. spinach and rhubarb) and phytic acid (e.g. whole cereals) may reduce calcium absorption by formation of insoluble calcium salts, thus calcium products should not be taken within 2 hr of eating such foods.

Dosage

Oral
Supplementation of calcium and vitamin D3
Adult: As effervescent tablet containing calcium carbonate 1500 mg and vitamin D3 10 mcg: 1 tablet bid, to be dissolved in a glass of water and taken immediately. Dosing regimen may vary with brands and dosage forms.

Food(before/after)

Information Not Available

List of Contraindications

Vitamin D3 + Calcium Carbonate and Pregnancy

Information Not Available

Vitamin D3 + Calcium Carbonate and Lactation

Information Not Available

Vitamin D3 + Calcium Carbonate and Children

Information Not Available

Vitamin D3 + Calcium Carbonate and Geriatic

Information Not Available

Vitamin D3 + Calcium Carbonate and Other Contraindications

Patients with hypercalcaemia and/or hypercalciuria. Nephrolithiasis, hypervitaminosis D, hypophosphataemia.

Storage

Oral
Store below 25°C.

Lab interference

Oral
Store below 25°C.

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