Metronidazole + Norfloxacin information from DrugsUpdate
L - Contraindicated in lactation
Information Not Available
Metronidazole is amoebicidal, bactericidal, and trichomonicidal. It is a nitroimidazole, active against various anaerobic bacteria and protozoa. It enters the cells of microorganisms that contain nitroreductase, where its nitro group is reduced. Unstable intermediate compounds are formed which bind to DNA and inhibit synthesis, causing cell death. Norfloxacin inhibits the action of DNA gyrase in DNA replication, transcription, repair, recombination and transposition.
Peripheral neuropathies. GI disturbances, rash, urticaria, pruritus, superinfection (candida), metallic taste, headache, dizziness, transient leucopaenia, paraesthesias, tongue, glossitis, pseudomembranous colitis (rare). Reduced serum levels of cholesterol, and triglycerides, nausea, vomiting, heart burn, constipation/diarrhoea, headache, dizziness, depression, insomnia, dry mouth, fever, arthralgia and anaemia. Elevated liver enzymes, urea and creatinine.
Potentially Fatal: Seizures, eosinophilia, neutropaenia, thrombocytopaenia.
Pregnancy, lactation renal/hepatic impairment. H/O convulsions. Ensure adequate hydration, urinary output. Patients predisposed to seizures.
Acute psychoses when metronidazole co-administered with disulfiram. It has additive/synergistic effect with other antimicrobials. Blood levels increased by cimetidine. Antacids reduce absorption of norfloxacin from GIT.
Potentially Fatal: Disulfiram-like reaction when metronidazole is administered with alcohol. Enhances action of coumarin anticoagulants. Norfloxacin raises theophylline and cyclosporin levels. Effects of warfarin are potentiated. Probenecid reduces urinary excretion of norfloxacin.
Diarrhoea caused by E.coli, samonella and shigella
Child: Per tablet contains metronidazole 500 mg and norfloxacin 400 mg: 1 tablet bid. Per 5 mL syrup contains metronidazole 100 mg and norfloxacin 100 mg: 5-10 mL bid.
List of Contraindications
Caution when used during pregnancy
Contraindicated in lactation
Hypersensitivity, blood dyscrasias, active CNS disease, serious neurological disease, neurological disease, seizures, alcohol, children, convulsions.
Metronidazole + Norfloxacin brands in India
Power Stop SUSP