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Idoxuridine information from DrugsUpdate  

See Available Brands of Idoxuridine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Idoxuridine is an anti-herpesvirus antiviral drug. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing.

Pharmacodynamics

Pharmacokinetics

Idoxuridine, a pyrimidine nucleoside structurally related to thymidine, inhibits viral replication by substituting itself for thymidine in viral DNA. It is active against herpes simplex and varicella zoster viruses, and has also been shown to inhibit vaccinia virus, cytomegalovirus and adenovirus.


Absorption Poor penetration into the skin and cornea.


Metabolism Metabolised rapidly in the body to iodouracil, uracil and iodide.


Excretion Metabolites are excreted in the urine.

Idoxuridine Indications / Idoxuridine Uses

Information Not Available

Idoxuridine Adverse Reactions / Idoxuridine Side Effects

Ophthalmic: Irritation; inflammation of the eye or eyelids; pain; photophobia; pruritus; conjunctivitis; oedema. Rarely, lachrymal duct occlusion and hypersensitivity reactions. Corneal damage (prolonged use). Topical: Irritation; stinging; hypersensitivity reactions; corneal punctate defects or skin maceration (when applied excessively).

Precautions

Information Not Available

Special Precautions

Deep ulceration of the stromal layers of the cornea. Avoid prolonged use. Pregnancy and lactation.

Other Drug Interactions

Corticosteroids may accelerate spread of viral infection.

Other Interactions

Information Not Available

Dosage

Ophthalmic Herpes simplex keratitis Adult: As 0.1% soln: Instill 1 drop in the affected eye(s) every hr. Taper to every 2 hr or 4 times daily. Continue treatment for at least 7 days. Topical/Cutaneous Cutaneous herpes simplex and herpes zoster Adult: As 5% preparation: Paint onto the lesions 4 times daily for 4 days.

Food(before/after)

Information Not Available

List of Contraindications

Idoxuridine and Pregnancy

Caution when used during pregnancy Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Idoxuridine and Lactation

Caution when used during lactation

Idoxuridine and Children

Information Not Available

Idoxuridine and Geriatic

Information Not Available

Idoxuridine and Other Contraindications

Hypersensitivity.

Storage

Ophthalmic Store between 36-80 ° F.

Lab interference

Ophthalmic Store between 36-80 ° F.

Idoxuridine brands in India:

Idurin Toxil

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