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Ciprofloxacin + Tinidazole information from DrugsUpdate  

See Available Brands of Ciprofloxacin + Tinidazole in India

P - Caution when used during pregnancy
L - Contraindicated in lactation
FI - Food *

Information Not Available

Pharmacodynamics

Pharmacokinetics

Ciprofloxacin is bactericidal against enteropathogens like Shigella, Salmonella, E coli, C jejuni, Vibrio cholerae etc. It acts by inhibition of DNA synthesis. Tinidazole is a potent anaerobicide. It is also effective against Entameba & Giardia. It acts by damaging DNA strands. This combination has the advantage of being effective against both bacteria & protozoa. Entameba requires normal faecal flora for its survival; ciprofloxacin kills the pathogenic intestinal bacteria & alters intestinal flora, & tinidazole directly eradicates Entameba. This combination can also be used in other systemic infections caused by susceptible organisms.

Ciprofloxacin + Tinidazole Indications / Ciprofloxacin + Tinidazole Uses

Information Not Available

Ciprofloxacin + Tinidazole Adverse Reactions / Ciprofloxacin + Tinidazole Side Effects

Nausea, headache, vomiting, fatigue, abdominal pain, depression, dyspepsia, constipation, dry mouth, sometimes diarrhea, metallic taste, urticaria, erythema & rashes; rarely convulsions & hematological changes.


Potentially Fatal: Severe hypersensitivity reaction (rarely).

Precautions

Overdosage
Unabsorbed drug may be removed by gastric lavage or induced emesis. Haemodialysis or peritoneal dialysis may be useful in removing ciprofloxacin, especially if the renal function is impaired.

Special Precautions

Renal impairment, history of seizures; ensure adequate hydration & urinary output; avoid alcohol ingestion. Not recommended for use in lactation and pregnancy. Not recommended for children. Patients with CNS disorders. Inadequate water intake during treatment may cause crystalluria.

Other Drug Interactions

Antacids, sucralfate, calcium, Fe & Zn prep reduce absorption of ciprofloxacin. Concurrent use with ciclosporin may lead to transient increases in serum creatinine levels. Increases plasma levels and elimination half-life of theophylline; potentiates oral anticoagulant effects; disulfiram-like effect with alcohol. May affect metabolism of caffeine resulting in reduced clearance of caffeine.

Other Interactions

Food Interactions
Milk and food may reduce rate but not extent of absorption of ciprofloxacin.

Dosage

Oral
Appendicitis, Diarrhoea and dysentery of protozoal, bacterial and mixed origin, Postoperative anaerobic infections, Pulmonary infections, Lung abscess
Adult: As tablet containing ciprofloxacin (mg)/tinidazole (mg): 500/600, 250/300. Usually 1 tablet bid for 5-10 days depending on severity and response.

Food(before/after)

Information Not Available

List of Contraindications

Ciprofloxacin + Tinidazole and Pregnancy

Caution when used during pregnancy

Ciprofloxacin + Tinidazole and Lactation

Contraindicated in lactation

Ciprofloxacin + Tinidazole and Children

Information Not Available

Ciprofloxacin + Tinidazole and Geriatic

Information Not Available

Ciprofloxacin + Tinidazole and Other Contraindications

Hypersensitivity, patients with a history of blood dyscrasias.

Storage

Information Not Available

Lab interference

Information Not Available

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