Gliclazide + Metformin information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
FI - Food*
Information Not Available
Pharmacodynamics
Pharmacokinetics
Information Not Available
Gliclazide + Metformin Indications / Gliclazide + Metformin Uses
Information Not Available
Gliclazide + Metformin Adverse Reactions / Gliclazide + Metformin Side Effects
Gliclazide: GI disturbances, skin reaction, leucopaenia, agranulocytosis, haemolytic anaemic, cholestatic jaundice, vomiting, diarrhoea, gastritis & increased transminases. Metformin: Anorexia, nausea, vomiting, diarrhoea, weight loss, flatulance, occasional metallic taste; weakness, hypoglycaemia, rash, malasbsorption of Vit B12. Severe hypoglycaemic. Lactic acidosisin presence or renal failure & alcoholism.
Precautions
Information Not Available
Special Precautions
Hypoglycaemia. May require insulin during metabolic stress. Care when transfering from combination therapy. Elderly. Monitor renal function regularly.
Other Drug Interactions
Gliclazide: Flushing with alcohol. Metformin: Additive effect with sulphonylureas. Antagonistic effects with diuretics, corticoteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotine acid, sympathomimetics & Ca channel blockers & isoniazid. Gliclazide: Hypoglycaemic effect increased by aspirin, phenylbutazone, clofibrate, sulphonamides, oral anticoagulants & MAOIs. Hypoglycaemic effect diminished by rifampicin, barbiturates, alcohol, diuretics, diazoxide, corticosteroids, beta- blockers, oestrogens & sympathomimetic drugs. Metformin: Lactic acidosis with alcohol & potentiation of hypoglycaemic effect. Cimetidine & furosemide may increase plasma- metformin levels. Drugs eliminated via renal tubular secretion may increase metformin levsls.
Other Interactions
Food Interaction
Dosage
Information Not Available
Food(before/after)
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List of Contraindications
Gliclazide + Metformin and Pregnancy
Contraindicated in pregnancy
Gliclazide + Metformin and Lactation
Contraindicated in lactation
Gliclazide + Metformin and Children
Information Not Available
Gliclazide + Metformin and Geriatic
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Gliclazide + Metformin and Other Contraindications
Hypersensitivity; type 1 diabetes mellitus, severe renal & hepatic impairment; diabetic coma, diabetic ketoacidosis, cardiac failure, recent MI, CHF; severe infection; acute or chronic metabolic acidosis with or without coma; stress trauma; severe impairment of thyroid function; dehydration; acute or chronic alcoholism. Pregnancy, lactation.
Storage
Information Not Available
Lab interference
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