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Chlordiazepoxide + Clidinium Bromide information from DrugsUpdate  

See Available Brands of Chlordiazepoxide + Clidinium Bromide in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Librax is used, in combination with other therapy, for the treatment of peptic ulcer, irritable bowel syndrome (spastic colon), and acute enterocolitis (inflammation of the colon and small intestine). Librax is a combination of a benzodiazepine (chlordiazepoxide) and an antispasmodic medication (clidinium).



Chlordiazepoxide exerts anxiolytic effect by stimulating the GABA receptor-complex activity. Clidinium is an anticholinergic agent. This combination can control some emotional and somatic factors in GI disease.

Chlordiazepoxide + Clidinium Bromide Indications / Chlordiazepoxide + Clidinium Bromide Uses

Information Not Available

Chlordiazepoxide + Clidinium Bromide Adverse Reactions / Chlordiazepoxide + Clidinium Bromide Side Effects

Mouth dryness, blurring, hesitancy and urgency in micturition, constipation, rise in body temperature, heat stroke, tachycardia, mydriasis, headache, nervousness, drowsiness, weakness, nausea, aggression, dependence, mild skin rashes and impaired psychomotor performance.

Potentially Fatal: Severe hypersensitive reaction, hemolytic anemia (rarely).


In debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia, oversedation or confusion (not more than 2 Chlordiazepoxide HCl/Clidinium Bromide capsules per day initially, to be increased gradually as needed and tolerated). In general, the concomitant administration of Chlordiazepoxide HCl/Clidinium Bromide and other psychotropic agents is not recommended. If such combination therapy seems indicated, careful consideration should be given to the pharmacology of the agents to be employed — particularly when the known potentiating compounds such as the MAO inhibitors and phenothiazines are to be used. The usual precautions in treating patients with impaired renal or hepatic function should be observed.

Paradoxical reactions to chlordiazepoxide hydrochloride, eg, excitement, stimulation and acute rage, have been reported in psychiatric patients and should be watched for during Chlordiazepoxide HCl/Clidinium Bromide therapy. The usual precautions are indicated when chlordiazepoxide hydrochloride is used in the treatment of anxiety states where there is any evidence of impending depression; it should be borne in mind that suicidal tendencies may be present and protective measures may be necessary. Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects on blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide hydrochloride.

Special Precautions

Driving, hazardous work, elderly, renal disease, hepatic disease, hypertension, CVS disease, ulcerative colitis, hernia, reflux esophagitis, elderly and debilitated, autonomic neuropathy.

Other Drug Interactions

Cimetidine increases T1/2 of chlordiazepoxide. Absorption of chlordiazepoxide enhanced by metoclopramide and aluminum hydroxide. Chlordiazepoxide absorption hindered by Mg trisilicate, morphine and pethidine. Clidinium faces additive anticholinergic effects with antidepressants, quinidine and some antihistamines.

Potentially Fatal: Alcohol potentiates chlordiazepoxide and concurrent use of both can be potentially dangerous.

Other Interactions

Information Not Available


Irritable bowel syndrome
Adult: Each capsule containing chlordiazepoxide 5 mg and clidinium 2.5 mg: 1-2 capsule 3-4 times a day, before meals and at bedtime.
Elderly: Minimal effective dose.


Should be taken on an empty stomach. (Take ½-1 hour before meals.)

List of Contraindications

Chlordiazepoxide + Clidinium Bromide and Pregnancy

Contraindicated in pregnancy

Chlordiazepoxide + Clidinium Bromide and Lactation

Contraindicated in lactation

Chlordiazepoxide + Clidinium Bromide and Children

Information Not Available

Chlordiazepoxide + Clidinium Bromide and Geriatic

Information Not Available

Chlordiazepoxide + Clidinium Bromide and Other Contraindications

Hypersensitivity, myasthenia gravis, pregnancy and lactation, glaucoma, obstructive uropathy, GI obstruction, paralytic ileus, unstable CVS status, acute hemorrhage, acute resp conditions.


Store at 25°C

Lab interference

Store at 25°C

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