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Ferrous Fumarate + Folic Acid information from DrugsUpdate  

See Available Brands of Ferrous Fumarate + Folic Acid in India

P - Caution when used during pregnancy

Ferrous fumarate and folic acid is used to treat iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body).

Pharmacodynamics

Pharmacokinetics

Ferrous fumarate is an iron compound that is used in the prevention and treatment of iron-deficient anaemia. Folic acid is a vitamin B that is used in the prevention and treatment of folate-deficient state. They are used together in pregnant women (2nd and 3rd trimesters) for the prevention of iron deficiency and megaloblastic anaemia of pregnancy.

Absorption
Ferrous fumarate: Absorption takes place mainly in the duodenum and jejunum; aided by gastric acid secretion. Folic acid: Absorption takes place mainly in the proximal part of the small intestine.

Distribution
Ferrous fumarate: Ferrous iron passes through the GI mucosal cells, bind to transferrin and is then transported to the bone marrow and incorporated into haemoglobin. Folic acid: Extensively bound to plasma proteins.

Metabolism
Folic acid: Largely metabolised in the liver.

Excretion
Ferrous fumarate: Mainly through the faeces and desquamation of cells e.g. skin, hair or GI mucosa. Folic acid: Mainly excreted in the urine.

Ferrous Fumarate + Folic Acid Indications / Ferrous Fumarate + Folic Acid Uses

Information Not Available

Ferrous Fumarate + Folic Acid Adverse Reactions / Ferrous Fumarate + Folic Acid Side Effects

GI discomfort, anorexia, nausea, vomiting, constipation, diarrhoea. Stool darkening may occur.

Precautions

Overdosage
Acute poisoning in young children is especially dangerous. Symptoms: Abdominal pain, vomiting and diarrhoea. CV collapse with coma may follow. In severe cases, deterioration may occur involving diffuse vascular congestion, pulmonary oedema, convulsions, anuria, hypothermia, severe shock and metabolic acidosis. Treatment includes inducing vomiting and gastric lavage. In severe cases, parenteral desferrioxamine may be used.

Special Precautions

Avoid use in patients with active peptic ulcer, repeated blood transfusion, regional enteritis and ulcerative colitis. Caution when used in patients with folate-dependent tumours. Not recommended for use during 1st trimester of pregnancy.

Other Drug Interactions

Concurrent admin may reduce the efficacy of fluoroquinolones, levodopa, carbidopa, thyroxine and bisphosphonates. Iron may reduce the absorption of penicillamine by forming complexes. Concurrent admin with tetracycline may lead to reduced absorption of tetracycline and iron. Antacids may reduce the absorption of iron. Serum levels of anticonvulsants may be reduced by folic acid.

Other Interactions

Information Not Available

Dosage

Oral
Prophylaxis of iron deficiency in pregnancy
Adult: Each tablet containing ferrous fumarate 322 mg and folic acid 0.35 mg. For pregnant women from 13th weeks of gestation onwards: 1 tablet daily.

Food(before/after)

Information Not Available

List of Contraindications

Ferrous Fumarate + Folic Acid and Pregnancy

Caution when used during pregnancy

Ferrous Fumarate + Folic Acid and Lactation

Information Not Available

Ferrous Fumarate + Folic Acid and Children

Information Not Available

Ferrous Fumarate + Folic Acid and Geriatic

Information Not Available

Ferrous Fumarate + Folic Acid and Other Contraindications

Paroxysmal nocturnal haemoglobinuria, haemosiderosis, haemochromatosis.

Storage

Oral
Store <25°C.

Lab interference

Oral
Store <25°C.

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