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Vitamin E information from DrugsUpdate  

See Available Brands of Vitamin E in India

Vitamin E is a generic term for tocopherols and tocotrienols. Vitamin E is a family of α-, β-, γ-, and δ-tocopherols and corresponding four tocotrienols. Vitamin E is a fat-soluble antioxidant that stops the production of reactive oxygen species formed when fat undergoes oxidation. Of these, α-tocopherol (also written as alpha-tocopherol) has been most studied as it has the highest bioavailability.

Pharmacodynamics

Pharmacokinetics

Vitamin E is a general term used to refer to a large number of natural or synthetic compounds. Tocopherols are the most common compounds, of which alpha tocopherols are the most active and widely distributed in nature. Alpha tocopherols occur naturally in the d optical isomer form and is more active than the synthetic racemic dl form. d-α-tocopheryl acetate is the acetate ester of natural source d-α-tocopherol. Other naturally occurring tocopherols e.g. beta, gamma, and delta tocopherols are not used clinically. Tocotrienols are another group of compounds with vitamin E activity. Vitamin E, a fat soluble vitamin, reacts with free radicals and protects RBCs against haemolysis and polysaturated fatty acids in membranes against free radical attack.

Absorption
20-80% (oral). Absorption depends on the presence of bile and on normal pancreatic function; decrease with increasing dose.

Distribution
Enters blood via the chylomicrons in the lymph; bound to β-lipoproteins. Widely distributed to all tissues. Stored in adipose tissue. Enters breast milk but crosses the placenta poorly.

Metabolism
Hepatic; converted to glucuronides of tocopheronic acid and its γ-lactone.

Excretion
Excreted mainly via bile into faeces and some into urine.

Vitamin E Indications / Vitamin E Uses

Information Not Available

Vitamin E Adverse Reactions / Vitamin E Side Effects

Hypertension; myopathy; thrombophloebitis; fatigue, weakness, nausea, headache, dizziness, blurred vision, flatulence, diarrhoea, abdominal pain. Topical: Contact dermatitis.

Precautions

Information Not Available

Special Precautions

Information Not Available

Other Drug Interactions

Colestyramine, colestipol, and orlistat may interfere with vitamin E absorption. High doses of vitamin E potentiates the anticoagulant action of warfarin. Large doses of vitamin E may impair response to iron supplementation.

Other Interactions

Information Not Available

Dosage

Oral
Vitamin E deficiency
Adult: 40-50 mg of d-α tocopherol daily.
Child: Neonate: 10 mg/kg once daily; 1 month–18 years: 2–10 mg/kg/day, up to 20 mg/kg.

Oral

Supplementation in cystic fibrosis
Adult: 100-200 mg daily of dl-α-tocoferil acetate or 67-135 mg daily of d-α-tocopherol.
Child: As α- tocopheryl acetate: 1 month–1 year 50 mg once daily; 1–12 year 100 mg once daily; 12–18 year 200 mg once daily. Dose to be adjusted as needed.

Oral
Abetalipoproteinaemia
Adult: 50-100 mg/kg daily of dl-α-tocoferil acetate or about 33-67 mg/kg daily of d-α-tocopherol.
Child: Neonate: 100 mg/kg once daily; 1 month–18 years: 50–100 mg/kg once daily.

Food(before/after)

Should be taken with food

List of Contraindications

Vitamin E and Pregnancy

Information Not Available

Vitamin E and Lactation

Information Not Available

Vitamin E and Children

Information Not Available

Vitamin E and Geriatic

Information Not Available

Vitamin E and Other Contraindications

Information Not Available

Storage

Information Not Available

Lab interference

Information Not Available

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