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Vaccine, DTP information from DrugsUpdate  

See Available Brands of Vaccine, DTP in India

P - Caution when used during pregnancy
L - Caution when used during lactation

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough) and tetanus. The vaccine components include diphtheria and tetanus toxoids, and killed whole cells of the organism that causes pertussis (wP).

DTaP (also DTPa and TDaP) refers to similar combination vaccines in which the pertussis component is acellular.

The usual course of childhood immunization is five doses between 2 months and 15 years. For adults, separate combination vaccines are used that adjust the relative concentrations of their components.

Pharmacodynamics

Pharmacokinetics

Vaccine, DTP is used for the active immunisation of diphtheria, tetanus and pertussis in children from 6 weeks to 6 years of age.

Vaccine, DTP Indications / Vaccine, DTP Uses

Information Not Available

Vaccine, DTP Adverse Reactions / Vaccine, DTP Side Effects

Pain, swelling and redness at the injection site. Fever, headache, fatigue and GI symptoms e.g. nausea, diarrhoea, abdominal pain.

Precautions

Information Not Available

Special Precautions

Caution when patient develops one or more of the following symptoms within 48 hours of vaccination: Temperature ≥40.5°C (not due to an identifiable cause), collapse or shock-like state or persistent and inconsolable crying lasting ≥3 hours. Seizures, with or without fever, within 3 days after vaccination. Patients who have experienced serious Arthus-type hypersensitivity reaction following a previous dose of tetanus toxoid should not receive tetanus toxoid-containing vaccine more frequently than once every 10 years. Caution when used in patients with family history of seizures or other CNS disorders. Not to be used in patients with bleeding disorders or patients on anticoagulant treatment unless benefit outweighs risk. Pregnancy and lactation.

Other Drug Interactions

Immune response to vaccines may be reduced in patients who are receiving immunosuppressive treatment e.g. cytotoxics, high dose corticosteroids, irradiation.

Other Interactions

Information Not Available

Dosage

Intramuscular
Active immunisation against diphtheria, tetanus and pertussis
Child: >6 weeks: For primary immunisation: 3 doses of 0.5 ml to be given at intervals of 4-8 weeks between doses (usually, at 2, 4 and 6 months of age). 4th dose should be given at about 15-20 months of age but at least 6 months from the 3rd dose. A 5th dose may be given to children at 4-6 years of age or prior to school-entry, if the 4th dose was received at younger than 4th years of age. Dose should be injected via deep IM injection into the anterolateral muscles of the thigh or the deltoid of the arm. Whenever possible, the same product should be used for all doses.

Intramuscular
Booster immunisation against diphtheria, tetanus and pertussis
Adult: Adacel®(19-64 years): 0.5 ml as a single dose, given via deep IM injection into the deltoid muscle of the upper arm. At least 5 years should have elapsed since the last dose of tetanus toxoid, diphtheria toxoid and/or pertussis containing vaccine. Shorter intervals (as short as 2 years) may be used in high-risk patients e.g. healthcare workers, or during pertussis outbreaks.
Child: Boostrix® (10-18 years) or Adacel®(11-18 years): 0.5 ml as a single dose, given via deep IM injection preferably into the deltoid muscle. At least 5 years should have elapsed since the last dose of tetanus toxoid, diphtheria toxoid and/or pertussis containing vaccine.

Intramuscular
Prophylaxis of tetanus in wound management
Adult: Adacel®: Patient should have completed the primary immunisation against tetanus; if wounds are minor and uncomplicated, a booster dose (0.5 ml) may be given if patient has not received any tetanus toxoid within the last 10 years; if wounds are tetanus-prone (e.g. contaminated with faeces, dirt or soil), a booster dose (0.5 ml) may be given if patient has not received tetanus toxoid within the last 5 years.
Child: Boostrix® (10-18 years) or Adacel® (11-18 years): Adolescents should have completed the primary immunisation against tetanus; if wounds are minor and uncomplicated, a booster dose (0.5 ml) may be given if patient has not received any tetanus toxoid within the last 10 years; if wounds are tetanus-prone (e.g. contaminated with faeces, dirt or soil), a booster dose (0.5 ml) may be given if patient has not received tetanus toxoid within the last 5 years.

Food(before/after)

Information Not Available

List of Contraindications

Vaccine, DTP and Pregnancy

Caution when used during pregnancy

Vaccine, DTP and Lactation

Caution when used during lactation

Vaccine, DTP and Children

Information Not Available

Vaccine, DTP and Geriatic

Information Not Available

Vaccine, DTP and Other Contraindications

Hypersensitivity. History of encephalopathy within 7 days of vaccination with pertussis-containing vaccine. Vaccine should not be used in patients with progressive neurologic disorder, progressive encephalopathy or uncontrolled epilepsy.

Storage

Intramuscular
Store at 2-8°C.

Lab interference

Intramuscular
Store at 2-8°C.

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